Journal of Toxicology / 2019 / Article / Tab 7

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 7

Results of the clinical chemistry evaluation in the 90-day study.

Group (mg/kg bw/day)ALTASTALPTBILCREAUREAGLUCCHOLPiCa++Na+K+ClALBTPROTA/G
[U/L][U/L][U/L][µmol/L][µmol/L][mmol/L][mmol/L][mmol/L][mmol/L][mmol/L][mmol/L][mmol/L][mmol/L][g/L][g/L]

Main study groups ()
Male
0 (Control)Mean40.995.387.71.0729.77.526.092.391.912.60144.534.37100.3244.2063.992.25
SD5.515.112.80.323.20.820.430.230.160.071.300.210.811.061.790.12
75Mean50.578.974.61.1225.77.905.772.872.052.63143.784.6198.7745.0264.862.28
SD15.88.316.70.293.40.930.550.290.170.060.580.331.411.382.860.19
SS
112Mean40.987.769.31.1129.87.945.483.272.142.66143.804.5897.8345.0565.782.20
SD3.815.210.00.314.61.000.650.350.190.092.290.232.741.362.180.26
SS
150Mean47.589.968.50.9530.07.245.683.672.272.71144.104.3597.7044.8164.052.36
SD9.37.413.10.213.30.990.820.390.060.090.840.200.962.193.120.27
SS
187Mean52.983.963.91.2227.68.066.013.631.992.62142.864.3297.2845.8964.422.47
SD9.59.517.50.472.71.530.900.630.290.091.420.121.940.831.620.21
SS
225Mean58.385.357.91.0629.67.005.294.122.122.63141.533.9695.9045.9765.332.38
SD10.010.015.60.233.10.580.640.380.150.091.690.221.551.632.910.22
SS
Test for significanceDNDNDNNSDNNSDNDNDNDNDNNSDN
Historical control range26.0–70.065.0–131.062.0–209.00.4–2.520.0–35.03.3–8.94.7–9.21.4–3.11.5–2.32.4–2.9141.2–148.44.1–5.296.8–103.240.1–47.359.9–70.11.5–2.6
Female
0 (Control)Mean48.799.741.51.8429.06.515.292.201.832.67143.594.24101.0849.6166.443.00
SD12.521.09.50.812.70.680.630.250.120.091.070.211.603.174.730.44
75Mean52.0101.650.90.9227.47.046.313.031.932.67142.254.4199.3048.0766.402.63
SD9.020.229.60.343.10.740.970.930.350.092.080.391.753.825.400.27
SS
112Mean46.084.637.81.1526.16.796.153.531.942.68141.864.1697.7748.4067.562.53
SD10.822.814.00.403.10.941.080.590.360.101.210.311.282.994.820.21
SS
150Mean50.084.253.51.0324.47.096.703.022.092.76141.474.4196.1348.7566.462.75
SD12.216.718.90.443.60.720.590.650.170.091.170.301.572.343.560.23
SS
187Mean56.380.339.61.2325.97.126.393.552.332.76140.384.4895.9446.8964.212.77
()SD7.36.27.80.403.11.590.621.020.190.101.030.192.092.894.490.38
SS
225Mean50.276.636.41.2425.06.736.183.452.292.77140.894.4295.6948.2565.562.79
SD13.48.910.30.373.01.250.510.830.140.090.750.261.581.652.370.20
SS
Test for significanceNSNSDNDNNSDNDNDNNSDNNSNSDN
Historical control range28.0–133.066.0–249.022.0–162.00.5–3.624.0–40.03.8–9.54.0–7.31.1–2.80.8–2.12.4–2.9140.9–146.53.1–4.697.6–105.043.8–57.656.5–78.91.7–3.7
Recovery groups
Male
0 (Control)Mean46.8096.6083.601.6628.607.606.092.202.112.67144.664.63100.3042.9662.882.18
SD6.3822.7017.290.403.361.301.000.150.090.041.410.211.360.972.000.28
225Mean40.2072.6071.601.4627.606.645.362.452.232.68143.644.6899.2243.1662.542.24
SD2.398.2611.010.291.140.310.250.360.110.020.340.110.571.370.900.23
Test for significanceNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNS
Female
0 (Control)Mean48.8095.2037.801.8436.806.765.641.941.392.59141.364.0499.4448.5666.562.72
SD9.6313.0813.770.435.761.090.370.380.210.051.050.290.762.253.770.28
225Mean37.8077.8036.401.8830.406.725.432.481.392.65142.024.2399.5848.8667.902.64
SD4.6024.2422.860.842.971.050.820.640.460.080.980.191.913.164.100.45
Test for significanceNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNS

Abbreviations: A/G, albumin to globulin ratio; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BAC, bile acids; Ca++, calcium; CHOL, cholesterol; Cl−, chloride; CREA, creatinine; DN, Duncan’s multiple range test; GLUC, glucose; K+, potassium; Na+, sodium; NS, Not Significant; Pi, inorganic phosphorous; SD, standard deviation; SS, statistically significant compared to control; TBIL, total bilirubin; TPROT, total protein; , Mann-Whitney -test versus control. Main group females at 187 mg/kg bw/day (; one animal died at collection due to over anesthesia). , .

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