Journal of Toxicology / 2019 / Article / Tab 8

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 8

Organ weights in the 90-day study.

Group (mg/kg bw/day)Organ weight (g)
Body weightBrainLiverKidneysHeartSpleenThymusTestesEpididymidesAdrenal glands

Main study groups
Male
0 (Control)Mean408.82.179.762.271.060.660.403.571.490.068
SD25.210.070.810.150.070.100.060.210.080.005
75Mean411.12.1310.792.511.040.710.353.691.450.072
SD29.760.090.770.370.100.080.040.270.210.010
SS
112Mean407.62.1411.012.561.030.680.303.531.370.067
SD17.090.080.700.270.100.080.060.330.210.010
SS
150Mean378.52.0710.432.500.960.590.263.261.230.068
SD27.320.081.000.240.060.090.040.380.150.014
SS
187Mean363.02.0410.482.520.930.600.263.251.190.068
SD26.920.110.950.310.100.080.060.240.160.010
SS
225Mean317.52.039.672.410.850.540.222.001.060.067
SD17.130.100.970.200.080.080.040.930.220.014
SS
Test for significanceDNDNDNNSDNDNDNDNNS
Historical control range363.0–548.02.00–2.358.20–14.601.95–3.190.93–1.370.51–0.930.25–0.592.99–4.431.20–1.190.041–0.091

FemaleOvariesUterus
0 (Control)Mean235.91.935.951.520.700.450.330.610.0910.081
SD10.950.080.540.090.040.050.050.120.0160.012
75Mean243.12.007.421.700.730.520.290.710.1020.080
SD8.700.090.670.070.050.050.060.140.0190.008
SS
112Mean235.61.897.721.740.720.510.300.640.0970.075
SD11.880.101.300.110.070.080.080.150.0190.010
SS
150Mean244.41.908.231.730.750.480.250.580.1180.074
SD14.680.100.740.110.050.060.030.100.0200.008
SS
187Mean247.21.958.921.820.760.490.300.620.1250.074
SD13.720.081.110.110.060.060.090.120.030.01
SS
225Mean231.61.838.811.710.710.440.220.530.1260.067
SD15.880.101.050.200.070.050.040.100.030.01
SS
Test for significanceNSDNDNNSDNNSDNDN
Historical control range208.0–297.01.83–2.175.18–8.531.36–2.340.63–0.850.32–0.560.18–0.470.42–1.110.07–0.140.063–0.104
Recovery groups
MaleTestesEpididymides
0 (Control)Mean457.42.2810.642.541.150.690.343.521.630.064
SD19.960.090.920.300.060.060.080.270.120.009
225Mean408.02.159.882.581.120.820.462.441.280.061
SD37.560.110.770.270.150.080.050.940.140.011
SS
Test for significanceNSNSNSNSNS

FemaleOvariesUterus
0 (Control)Mean244.02.085.981.550.740.470.250.630.0920.071
SD15.560.120.410.200.070.040.070.160.0150.008
225Mean235.01.966.721.610.750.490.350.760.0960.075
SD17.540.071.040.160.050.070.050.130.0120.013
SS
Test for significanceNSNSNSNSNSNSNSNSNS

Abbreviations: DN, Duncan’s multiple range test; NS, not Significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control. Remarks: Paired organs were weighed together. , .

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