A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 8

Organ weights in the 90-day study.

Group (mg/kg bw/day)		Organ weight (g)
		Body weight	Brain	Liver	Kidneys	Heart	Spleen	Thymus	Testes	Epididymides	Adrenal glands
Main study groups
Male
0 (Control)	Mean	408.8	2.17	9.76	2.27	1.06	0.66	0.40	3.57	1.49	0.068
	SD	25.21	0.07	0.81	0.15	0.07	0.10	0.06	0.21	0.08	0.005
75	Mean	411.1	2.13	10.79	2.51	1.04	0.71	0.35	3.69	1.45	0.072
	SD	29.76	0.09	0.77	0.37	0.10	0.08	0.04	0.27	0.21	0.010
	SS
112	Mean	407.6	2.14	11.01	2.56	1.03	0.68	0.30	3.53	1.37	0.067
	SD	17.09	0.08	0.70	0.27	0.10	0.08	0.06	0.33	0.21	0.010
	SS
150	Mean	378.5	2.07	10.43	2.50	0.96	0.59	0.26	3.26	1.23	0.068
	SD	27.32	0.08	1.00	0.24	0.06	0.09	0.04	0.38	0.15	0.014
	SS
187	Mean	363.0	2.04	10.48	2.52	0.93	0.60	0.26	3.25	1.19	0.068
	SD	26.92	0.11	0.95	0.31	0.10	0.08	0.06	0.24	0.16	0.010
	SS
225	Mean	317.5	2.03	9.67	2.41	0.85	0.54	0.22	2.00	1.06	0.067
	SD	17.13	0.10	0.97	0.20	0.08	0.08	0.04	0.93	0.22	0.014
	SS
Test for significance		DN	DN	DN	NS	DN	DN	DN		DN	NS
Historical control range		363.0–548.0	2.00–2.35	8.20–14.60	1.95–3.19	0.93–1.37	0.51–0.93	0.25–0.59	2.99–4.43	1.20–1.19	0.041–0.091
Female									Ovaries	Uterus
0 (Control)	Mean	235.9	1.93	5.95	1.52	0.70	0.45	0.33	0.61	0.091	0.081
	SD	10.95	0.08	0.54	0.09	0.04	0.05	0.05	0.12	0.016	0.012
75	Mean	243.1	2.00	7.42	1.70	0.73	0.52	0.29	0.71	0.102	0.080
	SD	8.70	0.09	0.67	0.07	0.05	0.05	0.06	0.14	0.019	0.008
	SS
112	Mean	235.6	1.89	7.72	1.74	0.72	0.51	0.30	0.64	0.097	0.075
	SD	11.88	0.10	1.30	0.11	0.07	0.08	0.08	0.15	0.019	0.010
	SS
150	Mean	244.4	1.90	8.23	1.73	0.75	0.48	0.25	0.58	0.118	0.074
	SD	14.68	0.10	0.74	0.11	0.05	0.06	0.03	0.10	0.020	0.008
	SS
187	Mean	247.2	1.95	8.92	1.82	0.76	0.49	0.30	0.62	0.125	0.074
	SD	13.72	0.08	1.11	0.11	0.06	0.06	0.09	0.12	0.03	0.01
	SS
225	Mean	231.6	1.83	8.81	1.71	0.71	0.44	0.22	0.53	0.126	0.067
	SD	15.88	0.10	1.05	0.20	0.07	0.05	0.04	0.10	0.03	0.01
	SS
Test for significance		NS	DN	DN		NS	DN		NS	DN	DN
Historical control range		208.0–297.0	1.83–2.17	5.18–8.53	1.36–2.34	0.63–0.85	0.32–0.56	0.18–0.47	0.42–1.11	0.07–0.14	0.063–0.104
Recovery groups
Male									Testes	Epididymides
0 (Control)	Mean	457.4	2.28	10.64	2.54	1.15	0.69	0.34	3.52	1.63	0.064
	SD	19.96	0.09	0.92	0.30	0.06	0.06	0.08	0.27	0.12	0.009
225	Mean	408.0	2.15	9.88	2.58	1.12	0.82	0.46	2.44	1.28	0.061
	SD	37.56	0.11	0.77	0.27	0.15	0.08	0.05	0.94	0.14	0.011
	SS
Test for significance			NS	NS	NS	NS					NS
Female									Ovaries	Uterus
0 (Control)	Mean	244.0	2.08	5.98	1.55	0.74	0.47	0.25	0.63	0.092	0.071
	SD	15.56	0.12	0.41	0.20	0.07	0.04	0.07	0.16	0.015	0.008
225	Mean	235.0	1.96	6.72	1.61	0.75	0.49	0.35	0.76	0.096	0.075
	SD	17.54	0.07	1.04	0.16	0.05	0.07	0.05	0.13	0.012	0.013
	SS
Test for significance		NS	NS	NS	NS	NS	NS		NS	NS	NS

Abbreviations: DN, Duncan’s multiple range test; NS, not Significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control. Remarks: Paired organs were weighed together. , .