A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 9

Percent organ weights relative to body weight in the 90-day study.

Group (mg/kg bw/day)		Brain	Liver	Kidneys	Heart	Spleen	Thymus	Testes	Epididymides	Adrenal glands
Main study groups
Male
0 (Control)	Mean	0.531	2.389	0.556	0.260	0.162	0.099	0.876	0.366	0.0167
	SD	0.034	0.156	0.033	0.018	0.023	0.018	0.065	0.031	0.0014
75	Mean	0.519	2.626	0.611	0.253	0.171	0.086	0.901	0.354	0.0174
	SD	0.038	0.067	0.077	0.019	0.010	0.010	0.070	0.061	0.0022
	SS
112	Mean	0.526	2.703	0.628	0.251	0.166	0.072	0.865	0.337	0.0165
	SD	0.020	0.173	0.064	0.019	0.020	0.011	0.075	0.051	0.0029
	SS
150	Mean	0.548	2.756	0.659	0.254	0.156	0.070	0.865	0.326	0.0181
	SD	0.036	0.167	0.028	0.014	0.021	0.014	0.111	0.033	0.0034
	SS
187	Mean	0.564	2.890	0.695	0.256	0.166	0.071	0.898	0.329	0.0187
	SD	0.037	0.203	0.070	0.026	0.021	0.013	0.077	0.034	0.0026
	SS
225	Mean	0.642	3.041	0.760	0.269	0.169	0.070	0.625	0.332	0.0212
	SD	0.050	0.173	0.060	0.014	0.018	0.012	0.270	0.060	0.0038
	SS
Test for significance		DN	DN		NS	NS	DN	NS	NS	DN
Historical control range		0.403–0.606	2.055–3.156	0.452–0.634	0.211–0.284	0.119–0.194	0.063–0.129	0.642–0.963	0.279–0.424	0.009–0.020
Female								Ovaries	Uterus
0 (Control)	Mean	0.817	2.519	0.642	0.298	0.189	0.139	0.261	0.0387	0.0343
	SD	0.039	0.152	0.022	0.020	0.022	0.018	0.054	0.0081	0.0046
75	Mean	0.821	3.055	0.701	0.302	0.214	0.121	0.294	0.0418	0.0327
	SD	0.038	0.292	0.026	0.024	0.020	0.026	0.060	0.0079	0.0026
	SS
112	Mean	0.804	3.270	0.738	0.305	0.216	0.125	0.270	0.0413	0.0318
	SD	0.062	0.478	0.038	0.017	0.031	0.030	0.056	0.0076	0.0047
	SS
150	Mean	0.781	3.373	0.707	0.306	0.198	0.101	0.237	0.0482	0.0304
	SD	0.059	0.284	0.038	0.023	0.029	0.016	0.043	0.0083	0.0032
	SS
187	Mean	0.789	3.607	0.736	0.307	0.199	0.122	0.251	0.0505	0.0297
	SD	0.04	0.39	0.04	0.02	0.02	0.03	0.04	0.01	0.00
	SS
225	Mean	0.794	3.808	0.736	0.307	0.191	0.096	0.226	0.0549	0.0291
	SD	0.05	0.45	0.06	0.02	0.02	0.01	0.04	0.01	0.01
	SS
Test for significance		NS		DN	NS	DN		NS	DN	DN
Historical control range		0.731–1.000	2.183–3.189	0.508–0.951	0.236–0.333	0.139–0.227	0.078–0.169	0.161–0.465	0.029–0.054	0.025–0.045
Recovery groups
Male								Testes	Epididymides
0 (Control)	Mean	0.498	2.326	0.556	0.251	0.151	0.074	0.772	0.357	0.014
	SD	0.030	0.170	0.061	0.011	0.017	0.015	0.067	0.028	0.002
225	Mean	0.530	2.426	0.632	0.275	0.202	0.114	0.599	0.314	0.015
	SD	0.047	0.109	0.029	0.016	0.013	0.012	0.219	0.015	0.002
	SS
Test for significance		NS	NS					NS		NS
Female								Ovaries	Uterus
0 (Control)	Mean	0.855	2.454	0.636	0.304	0.194	0.103	0.255	0.0376	0.0292
	SD	0.067	0.099	0.093	0.025	0.020	0.024	0.052	0.0055	0.0037
225	Mean	0.835	2.859	0.683	0.320	0.208	0.152	0.321	0.0415	0.0319
	SD	0.049	0.355	0.032	0.009	0.031	0.029	0.045	0.0079	0.0042
	SS
Test for significance		NS		NS	NS	NS		NS	NS	NS

Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control. Remarks: Paired organs were weighed together. , .