Journal of Toxicology / 2019 / Article / Tab 9

Research Article

A Toxicological Evaluation of Methylliberine (Dynamine®)

Table 9

Percent organ weights relative to body weight in the 90-day study.

Group (mg/kg bw/day)BrainLiverKidneysHeartSpleenThymusTestesEpididymidesAdrenal glands

Main study groups
Male
0 (Control)Mean0.5312.3890.5560.2600.1620.0990.8760.3660.0167
SD0.0340.1560.0330.0180.0230.0180.0650.0310.0014
75Mean0.5192.6260.6110.2530.1710.0860.9010.3540.0174
SD0.0380.0670.0770.0190.0100.0100.0700.0610.0022
SS
112Mean0.5262.7030.6280.2510.1660.0720.8650.3370.0165
SD0.0200.1730.0640.0190.0200.0110.0750.0510.0029
SS
150Mean0.5482.7560.6590.2540.1560.0700.8650.3260.0181
SD0.0360.1670.0280.0140.0210.0140.1110.0330.0034
SS
187Mean0.5642.8900.6950.2560.1660.0710.8980.3290.0187
SD0.0370.2030.0700.0260.0210.0130.0770.0340.0026
SS
225Mean0.6423.0410.7600.2690.1690.0700.6250.3320.0212
SD0.0500.1730.0600.0140.0180.0120.2700.0600.0038
SS
Test for significanceDNDNNSNSDNNSNSDN
Historical control range0.403–0.6062.055–3.1560.452–0.6340.211–0.2840.119–0.1940.063–0.1290.642–0.9630.279–0.4240.009–0.020

FemaleOvariesUterus
0 (Control)Mean0.8172.5190.6420.2980.1890.1390.2610.03870.0343
SD0.0390.1520.0220.0200.0220.0180.0540.00810.0046
75Mean0.8213.0550.7010.3020.2140.1210.2940.04180.0327
SD0.0380.2920.0260.0240.0200.0260.0600.00790.0026
SS
112Mean0.8043.2700.7380.3050.2160.1250.2700.04130.0318
SD0.0620.4780.0380.0170.0310.0300.0560.00760.0047
SS
150Mean0.7813.3730.7070.3060.1980.1010.2370.04820.0304
SD0.0590.2840.0380.0230.0290.0160.0430.00830.0032
SS
187Mean0.7893.6070.7360.3070.1990.1220.2510.05050.0297
SD0.040.390.040.020.020.030.040.010.00
SS
225Mean0.7943.8080.7360.3070.1910.0960.2260.05490.0291
SD0.050.450.060.020.020.010.040.010.01
SS
Test for significanceNSDNNSDNNSDNDN
Historical control range0.731–1.0002.183–3.1890.508–0.9510.236–0.3330.139–0.2270.078–0.1690.161–0.4650.029–0.0540.025–0.045
Recovery groups

MaleTestesEpididymides
0 (Control)Mean0.4982.3260.5560.2510.1510.0740.7720.3570.014
SD0.0300.1700.0610.0110.0170.0150.0670.0280.002
225Mean0.5302.4260.6320.2750.2020.1140.5990.3140.015
SD0.0470.1090.0290.0160.0130.0120.2190.0150.002
SS
Test for significanceNSNSNSNS

FemaleOvariesUterus
0 (Control)Mean0.8552.4540.6360.3040.1940.1030.2550.03760.0292
SD0.0670.0990.0930.0250.0200.0240.0520.00550.0037
225Mean0.8352.8590.6830.3200.2080.1520.3210.04150.0319
SD0.0490.3550.0320.0090.0310.0290.0450.00790.0042
SS
Test for significanceNSNSNSNSNSNSNS

Abbreviations: DN, Duncan’s multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; -test versus control; , Mann-Whitney -test versus control. Remarks: Paired organs were weighed together. , .

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