Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®)

Table 3

Summary results of the in vivo mammalian micronucleus test.

Groups (n = 5)	Sampling time	Total PCEs analyzed	MPCE		PCE/(PCE+NCE)
			(per 4000 PCE)
			mean	±SD	mean	±SD
Hist. Neg. Control	24	280000	5.11	0.98	–	–
Con. Neg. Control	24	20000	5.40	1.14	0.53	0.01
500 mg/kg bw	24	20000	5.00	1.41	0.54	0.02
1000 mg/kg bw	24	20000	5.20	0.84	0.52	0.01
2000 mg/kg bw	24	20000	5.40	0.89	0.48	0.01
Positive Control	24	20000	148.20	8.17	0.39	0.02

Con. Neg. Control, concurrent negative control; Hist. Neg. Control, historical negative control; MPCE, micronucleated polychromatic erythrocytes; NCE, normochromatic erythrocyte; PCE, polychromatic erythrocyte.
Positive Control: Cyclophosphamide (60 mg/kg bw).
Historical negative control (n = 70).
Hours following last treatment.
p < 0.01 to the concurrent and historical negative control; Kruskall Wallis nonparametric ANOVA.