Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®)

Table 4

Hematology in the 28-day study.

Group		WBC	NEU	LYM	MONO	EOS	BASO	RBC	HGB	HCT	MCV	MCH	MCHC	PLT	RET	PT	APTT
(mg/kg bw/day)		[x10^9/L]	[%]	[%]	[%]	[%]	[%]	[x10^12/L]	[g/L]	[L/L]	[fL]	[pg]	[g/L]	[x10^9/L]	[%]	[sec]	[sec]
Male
0 (Control)	Mean	8.39	14.88	81.35	2.05	1.01	0.12	8.78	160.5	0.48	55.16	18.26	331.0	884.1	2.00	10.39	13.31
(n = 10)	SD	2.40	7.24	7.85	0.70	0.63	0.04	0.28	5.74	0.02	0.92	0.47	7.3	195.1	0.31	0.21	1.69
400	Mean	8.81	12.42	84.05	1.97	0.83	0.10	8.64	158.2	0.48	55.82	18.32	328.3	889.7	2.13	10.44	14.39
(n = 10)	SD	1.19	4.76	5.41	0.71	0.35	0.05	0.12	2.74	0.01	1.10	0.45	4.8	114.7	0.32	0.19	0.50
800	Mean	8.76	12.17	84.38	1.82	0.94	0.10	8.69	159.0	0.48	55.55	18.33	329.8	885.0	2.15	10.28	13.01
(n = 10)	SD	1.39	4.33	4.67	0.48	0.75	0.00	0.26	4.14	0.01	1.55	0.38	8.2	153.2	0.31	0.19	0.60
1200	Mean	8.62	12.86	83.77	2.04	0.74	0.10	8.60	156.2	0.48	55.64	18.19	327.0	856.3	2.52	10.27	12.94
(n = 10)	SD	1.72	3.37	4.00	0.58	0.27	0.05	0.45	9.17	0.03	1.47	0.67	13.8	64.6	0.35	0.25	1.25
	SS
Test for Significance		NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	DN	NS	NS
Historical Control Range		4.9–11.2	7.6–16.2	78.8–89.0	1.3–3.3	0.4-7.9	0.0–0.2	7.80–8.76	151–172	0.45–0.50	54.4–59.8	18.1–20.8	334–356	638–1100	2.37–4.04	9.8–10.7	9.9–15.8
Female
0 (Control)	Mean	7.19	15.57	80.77	1.92	1.00	0.10	8.45	154.9	0.47	56.17	18.36	327.2	866.8	2.46	10.05	13.63
(n = 10)	SD	1.45	3.81	4.08	0.44	0.24	0.05	0.42	4.1	0.01	1.72	0.59	5.7	134.8	0.36	0.27	1.25
400	Mean	5.77	15.23	80.98	1.91	1.28	0.09	8.49	156.2	0.48	55.94	18.43	329.4	912.0	2.56	10.14	14.03
(n = 10)	SD	0.85	4.67	5.01	0.55	0.41	0.03	0.32	6.4	0.01	1.11	0.39	6.4	92.9	0.34	0.25	1.44
800	Mean	6.62	11.41	84.90	1.66	1.35	0.09	8.54	157.5	0.49	57.19	18.44	322.4	893.3	2.40	10.03	14.07
(n = 10)	SD	2.04	2.10	2.90	0.47	0.97	0.06	0.26	4.5	0.01	1.63	0.45	5.7	122.0	0.48	0.29	1.10
	SS
1200	Mean	6.20	14.93	80.27	2.12	1.92	0.08	8.41	156.3	0.47	56.51	18.57	328.8	910.7	2.46	9.97	13.61
(n = 10)	SD	1.43	5.53	7.53	0.62	2.44	0.04	0.27	5.4	0.02	1.11	0.44	5.3	182.5	0.38	0.17	1.25
Test for Significance		NS	NS	NS	NS	NS	NS	NS	NS	DN	NS	NS	NS	NS	NS	NS	NS
Historical Control Range		3.5–8.3	6.5–26.9	67.7–90.8	0.9–3.2	0.6–4.4	0.0–0.2	7.47–8.85	145–172	0.41–0.49	52.6–60.0	17.8–20.8	327–361	768–1230	1.86–3.44	9.5–10.0	9.6–19.1

APTT, activated partial thromboplastin time; BASO, basophil granulocytes; DN, Duncan’s multiple range test; EOS, eosinophil granulocytes; HCT, hematocrit; HGB, hemoglobin; LYM, lymphocyte; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MONO, monocyte; NEU, neutrophil granulocytes; NS, not significant; PLT, platelet count; PT, prothrombin time; RBC, red blood cell (erythrocyte); RET, reticulocyte; SD, standard deviation; SS, statistically significant compared to control; WBC, white blood cell.
p < 0.05; p < 0.01.