Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®)
Table 6
Summary of histopathology findings.
Dose group (mg/kg bw/day)
Control
400
800
1200
Organs
Observations
n=10
N/A
N/A
n=10
Male
Animals with no microscopic findings
7/10
N/A
N/A
6/10
Kidneys:
Pelvic dilatation, slight
2/10
2/2
2/2
2/10
Liver:
Focal interstitial fibrosis, mild
1/10
/
/
0/10
Lungs:
Acute pulmonary hemorrhage, mild
0/10
/
/
1/10
Alveolar emphysema, minimal
1/10
/
/
1/10
Hyperplasia of BALT, minimal to mild
1/10
/
/
1/10
Thymus:
Acute hemorrhage, mild
0/10
/
/
1/10
Female
Animals with no microscopic findings
5/10
N/A
N/A
7/10
Kidneys:
Pelvic dilatation, slight
2/10
1/1
2/2
0/10
Lungs:
Alveolar emphysema, minimal
1/10
/
/
1/10
Hyperplasia of BALT, minimal
1/10
/
/
0/10
Thymus:
Acute hemorrhage, mild
1/10
/
/
0/10
Uterus:
Dilatation
2/10
/
/
2/10
/, not examined; BALT, bronchus associated lymphoid tissue; N/A, not applicable (only animals with gross lesions were examined). Data represent incidence of the observation (number of animals with observation per number of animals observed). Organs without lesions in 10/10 control or high-dose animals not shown. Matching superscripts represent findings observed in the same animal.
