Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats
Table 2
Biochemical evaluation for acute toxicity.
Control
100mg/kg
200mg/kg
300mg/kg
400mg/kg
500mg/kg
Creatinine (µmol/L)
25.22 ± 1.13
25.13 ± 1.11
24.00 ± 2.15
24.52 ± 2.14
25.00 ± 1.22
26.24 ± 1.14
Urea (mmol/L)
5.95 ± 0.33
5.60 ± 0.15
5.87 ± 0.13
5.90 ± 0.21
5.91 ± 0.32
5.85 ± 0.15
Albumin (g/L)
35.9 ± 3.2
34.6 ± 3.7
34.2 ± 7.8
34.3 ± 3.2
33.5 ± 5.3
33.2 ± 4.3
Globulin (g/L)
23.2 ± 2.8
21.5 ± 1.8
22.3 ± 3.1
22.6 ± 2.9
21.2 ± 4.2
21.3 ± 3.9
Total bilirubin (µmol/L)
2.0 ± 0.8
2.1 ± 0.7
2.0 ± 0.5
1.9 ± 0.4
1.9 ± 0.7
2.1 ± 0.9
Alkaline phosphatase (U/L)
432 ± 11
424 ± 29
431 ± 26
422 ± 13
420 ± 14
435 ± 17
Alanine aminotransferase (U/L)
118 ± 31
119 ± 11
116 ± 21
120 ± 10
117 ± 18
115 ± 12
Aspartate aminotransferase (U/L)
153 ± 56
155 ± 32
153 ± 21
152 ± 42
155 ± 23
152 ± 32
The results are expressed as the mean ±Standard error, (n=7). No significant difference could be detected between the different groups vs the control group; Control, the normal control group; 100 mg/kg, 100 mg/kg GTN- intraperitoneal treated group; 200 mg/kg, 200 mg/kg GTN- intraperitoneal treated group; 300 mg/kg, 300 mg/kg GTN- intraperitoneal treated group; 400 mg/kg, 400 mg/kg GTN- intraperitoneal treated group; 500 mg/kg, 500 mg/kg GTN- intraperitoneal treated group.
