Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice

Figure 5

Histopathological evaluation of chronic Cd exposure (cadmium chloride; 1 mg.kg⁻¹, intraperitoneal injection, twice weekly) on pancreas tissue in male C57BL/6 mice (n=5/group) (a): (A), (B): 100×; (C), (D): 400×. Tissue samples were fixed in 4% neutral buffered formalin, embedded in paraffin, sectioned, and stained with H&E. (A), (C): pancreas tissue of control mice; (B), (D): pancreas tissue of chronic Cd-exposed mice showing islet atrophy. (b): islet numbers in control and Cd-exposed mice. (c): the areas of pancreatic islets in control and Cd-exposed mice.

(a)

(b)

(c)