An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease

Figure 1

A schematic representation of the adverse outcome pathway (AOP). An AOP starts with a molecular initiating event (MIE) which is triggered by exposure to a substance of interest that interacts or reacts with a biological target, often a molecule. This MIE leads to a sequential series of intermediate key events (KE) along the different levels of biological organization to produce an adverse outcome (AO). A and B represent the relationships between two unique key events (KERs).