Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 1

Effect of oral administration of GMCT on feed consumption by male Wistar rats.

Feed consumption (g/week/animal)
Days	Primary groups Dose (mg/kg/day)				Reversal groups Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
1–7	137.51 ± 6.90	137.87 ± 0.26	134.96 ± 3.80	128.21 ± 4.24	141.31 ± 1.98	132.87 ± 7.47^#
8–14	133.36 ± 3.48	138.87 ± 8.91	141.85 ± 10.06	132.77 ± 13.93	140.93 ± 1.50	132.00 ± 7.50^#
15–21	139.57 ± 10.18	148.31 ± 0.49	140.68 ± 8.66	131.80 ± 12.31	139.51 ± 1.41	128.81 ± 4.90^#
22–28	123.55 ± 4.85	135.28 ± 4.61	123.09 ± 4.13	119.27 ± 14.62	143.83 ± 1.80	143.09 ± 4.66
29–35	—	—	—	—	144.51 ± 1.48	139.84 ± 8.30
36–42	—	—	—	—	123.37 ± 1.15	117.14 ± 5.67^#
Total feed consumption from day 1 (g, mean ± SD)
	533.99 ± 25.41	563.30 ± 14.27	540.58 ± 26.65	512.05 ± 45.10	833.46 ± 9.32	793.75 ± 38.51

Data are present as mean ± SD; n = 5. and ^#Significance vs. G1 and G1R, respectively.