Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
Table 10
Effect of oral administration of GMCT on biochemical parameters in female Wistar rats.
Parameters
Primary groups Dose (mg/kg/day)
Reversal groups Dose (mg/kg/day)
0 (G1)
250 (G2)
500 (G3)
1000 (G4)
0 (G1R)
1000 (G4R)
Glu (mg/dL)
110.60 ± 10.48
107.80 ± 7.46
99.80 ± 8.76
109.00 ± 10.95
102.40 ± 5.03
118.0 ± 13.32#
BUN (mg/dL)
17.80 ± 0.45
19.60 ± 4.51
21.40 ± 3.91
19.40 ± 2.70
18.80 ± 2.05
20.80 ± 2.17
Ur (mg/dL)
38.80 ± 1.10
42.00 ± 9.14
45.60 ± 8.32
41.60 ± 6.19
40.00 ± 3.94
44.40 ± 4.39
Crea (mg/dL)
0.54 ± 0.04
0.55 ± 0.04
0.52 ± 0.06
0.55 ± 0.05
0.54 ± 0.04
0.55 ± 0.08
T.Chol (mg/dL)
38.20 ± 7.92
39.20 ± 10.26
37.80 ± 7.29
41.80 ± 4.97
35.00 ± 6.40
48.00 ± 7.04#
Trig (mg/dL)
79.60 ± 66.59
91.80 ± 63.38
58.20 ± 13.14
65.80 ± 22.59
77.20 ± 32.48
82.60 ± 34.96
T.Bil (mg/dL)
0.06 ± 0.03
0.05 ± 0.03
0.05 ± 0.04
0.09 ± 0.03
0.11 ± 0.02
0.10 ± 0.05
AST (U/L)$
80.00 ± 4.95
96.60 ± 6.47
90.20 ± 7.19
81.20 ± 5.72
89.00 ± 9.35
95.80 ± 25.79
ALT (U/L)$
31.40 ± 1.95
35.40 ± 5.18
39.4 ± 4.93
46.00 ± 11.11
38.80 ± 6.83
35.20 ± 8.26
ALP (U/L)
39.80 ± 8.76
49.00 ± 15.73
41.00 ± 5.70
47.40 ± 13.74
37.40 ± 16.32
36.20 ± 14.31
TP (g/dL)
6.79 ± 0.22
6.82 ± 0.40
6.66 ± 0.38
6.80 ± 0.29
6.98 ± 0.19
7.18 ± 0.27
Alb (g/dL)
4.38 ± 0.15
4.28 ± 0.19
4.28 ± 0.27
4.34 ± 0.26
4.30 ± 0.14
4.24 ± 0.28
Ca (mg/dL)
10.56 ± 0.25
10.10 ± 0.19
10.20 ± 0.21
10.38 ± 0.49
10.48 ± 0.13
10.44 ± 0.17
Phos (mg/dL)
4.88 ± 0.50
4.46 ± 0.23
5.30 ± 0.52
5.16 ± 0.29
4.16 ± 0.48
4.68 ± 0.66
Na (mmoL/L)
141.16 ± 1.03
141.74 ± 0.65
140.44 ± 0.96
141.46 ± 1.02
141.70 ± 0.69
141.74 ± 0.65
K (mmoL/L)
3.50 ± 0.28
3.37 ± 0.15
3.65 ± 0.19
3.54 ± 0.15
3.52 ± 0.20
3.59 ± 0.17
Cl (mmoL/L)
105.54 ± 1.33
105.82 ± 0.79
104.04 ± 0.91
105.54 ± 1.16
106.24 ± 0.91
105.54 ± 1.77
Data are present as mean ± SD; n = 5. and #Significance vs. G1 and G1R, respectively. $The mean ± SD of the historical values of AST is 107.75 ± 33.30 U/L (min. 70.0 U/L; max. 167.0 U/L) and ALT is 41.47 ± 9.08 U/L (min. 25.0 U/L; 67.0 U/L).
