Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 11

Summary of histopathological observations on the vital organs of male Wistar rats after 28 days of oral supplementation of GMCT.

Organs/findings	Number of animals showing abnormal findings (severity score)
	GMCT dose (mg/kg/day)
	0 (G1)	1000 (G4)
Adrenals
Cortical tissue, accessory	1 (+)	1 (+)
Cecum
Infiltration, MNC, mucosa	1 (+)	1 (+)
Kidneys
Mineralization, tubular, outer medulla	0	1 (+)
Liver	0	0
Lungs
Haemorrhage, alveolar	0	1 (++)
Mineralization/bone formation, alveolar	1 (+)	0
Pancreas
Degeneration/atrophy, acinar	1 (+)	1 (+)
Pituitary gland
Distension/secretion, Rathke’s cleft	1 (+)	0
Pseudocyst, pars intermedia	1 (+)	0
Thymus
Haemorrhage, medulla	0	1 (+)
Haemorrhage, medulla	1 (++)	0
Necrosis, lymphocytes, cortex	0	1 (++)
Trachea
Glandular dilation, submucosa	1 (+)	0
Urinary bladder
Eosinophilic material (seminal plug), lumen	1 (++)	0
Luminal dilation	0	1 (++)
Testes
Mineralization and degeneration, seminiferous epithelium, tubular	0	1 (+)
Epididymis
Infiltration, MNC, interstitial	0	1 (+)
Prostate gland
Infiltration, MNC, interstitial	0	1 (+)

n = 5; scores (+) and (++) indicate minimal and mild abnormality, respectively.