Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 14

Effect of GMCT supplementation on micronucleus frequency in mouse bone marrow erythrocytes.

Treatments	Dose (mg/kg)	Male (n = 5)		Female (n = 5)
		PCE : TE	% MNPCE	PCE : TE	% MNPCE
Vehicle control	0	0.642 ± 0.038	0.080 ± 0.048	0.591 ± 0.021	0.110 ± 0.058
GMCT	500	0.625 ± 0.036	0.0035 ± 0.034	0.595 ± 0.041	0.025 ± 0.035
GMCT	1,000	0.612 ± 0.030	0.020 ± 0.033	0.616 ± 0.025	0.040 ± 0.038
GMCT	2,000	0.600 ± 0.032	0.015 ± 0.022	0.616 ± 0.029	0.020 ± 0.027
Cyclophosphamide monohydrate	40	0.618 ± 0.045	1.900 ± 0.083	0.612 ± 0.038	1.910 ± 0.068

Data are present as mean ± SD; , comparison between treatment and control groups in one-way ANOVA. MNPCE = micronucleated polychromatic erythrocyte; PCE = polychromatic erythrocytes; TE = total erythrocytes.