Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 5

Effect of oral administration of GMCT on absolute and relative organ weights of male Wistar rats.

Organs	Primary groups; Dose (mg/kg/day)				Reversal groups; Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
Liver
Absolute weight (g)	10.98 ± 1.26	11.69 ± 1.04	11.05 ± 1.59	10.27 ± 1.57	10.74 ± 1.20	10.25 ± 1.30
% body weight	3.29 ± 0.25	3.48 ± 0.34	3.28 ± 0.25	3.14 ± 0.28	2.90 ± 0.10	2.87 ± 0.23
Kidney
Absolute weight (g)	2.33 ± 0.24	2.35 ± 0.14	2.38 ± 0.37	2.24 ± 0.24	2.44 ± 0.26	2.31 ± 0.20
% body weight	0.70 ± 0.04	0.70 ± 0.03	0.71 ± 0.05	0.69 ± 0.05	0.66 ± 0.05	0.65 ± 0.03
Adrenals
Absolute weight (g)	0.06 ± 0.01	0.05 ± 0.01	0.06 ± 0.01	0.06 ± 0.01	0.06 ± 0.01	0.06 ± 0.00
% body weight	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.02 ± 0.00
Heart
Absolute weight (g)	1.09 ± 0.13	1.11 ± 0.15	1.09 ± 0.15	0.98 ± 0.06	1.02 ± 0.07	1.02 ± 0.08
% body weight	0.33 ± 0.04	0.33 ± 0.04	0.32 ± 0.03	0.3 ± 0.02	0.28 ± 0.01	0.29 ± 0.02
Brain
Absolute weight (g)	2.01 ± 0.14	1.95 ± 0.07	1.98 ± 0.11	2.01 ± 0.09	2.07 ± 0.05	2.03 ± 0.15
% body weight	0.60 ± 0.02	0.58 ± 0.04	0.59 ± 0.04	0.62 ± 0.04	0.56 ± 0.04	0.57 ± 0.03
Spleen
Absolute weight (g)	0.68 ± 0.08	0.99 ± 0.60	0.61 ± 0.09	0.68 ± 0.07	0.70 ± 0.08	0.67 ± 0.12
% body weight	0.20 ± 0.01	0.30 ± 0.19	0.18 ± 0.02	0.21 ± 0.02	0.19 ± 0.01	0.19 ± 0.03
Thymus
Absolute weight (g)	0.44 ± 0.07	0.39 ± 0.07	0.38 ± 0.11	0.41 ± 0.10	0.35 ± 0.03	0.31 ± 0.04
% body weight	0.13 ± 0.02	0.12 ± 0.02	0.11 ± 0.03	0.12 ± 0.02	0.09 ± 0.01	0.09 ± 0.01
Testes
Absolute weight (g)	3.59 ± 0.35	3.39 ± 0.30	3.44 ± 0.41	3.24 ± 0.46	3.61 ± 0.23	3.71 ± 0.19
% body weight	1.08 ± 0.08	1.01 ± 0.07	1.02 ± 0.10	0.99 ± 0.11	0.98 ± 0.13	1.04 ± 0.04
Epididymides
Absolute weight (g)	1.11 ± 0.12	1.07 ± 0.09	1.03 ± 0.15	0.96 ± 0.17	1.21 ± 0.14	1.26 ± 0.08
% body weight	0.33 ± 0.03	0.32 ± 0.04	0.31 ± 0.02	0.29 ± 0.04	0.33 ± 0.05	0.35 ± 0.02
Seminal vesicles and prostate
Absolute weight (g)	2.07 ± 0.32	2.32 ± 0.43	2.15 ± 0.41	2.10 ± 0.11	2.17 ± 0.18	2.23 ± 0.26
% body weight	0.62 ± 0.10	0.69 ± 0.15	0.64 ± 0.13	0.65 ± 0.08	0.59 ± 0.07	0.63 ± 0.09

n = 5; data are present as mean ± SD; no significance.