Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Table 6

Effect of oral administration of GMCT on absolute and relative organ weights of female Wistar rats.

Organs	Primary groups; Dose (mg/kg/day)				Reversal groups; Dose (mg/kg/day)
	0 (G1)	250 (G2)	500 (G3)	1000 (G4)	0 (G1R)	1000 (G4R)
Liver
Absolute weight (g)	6.57 ± 0.68	6.57 ± 1.12	6.79 ± 0.31	7.29 ± 0.89	6.24 ± 0.60	6.56 ± 0.22
% body weight	3.07 ± 0.20	3.16 ± 0.37	3.17 ± 0.06	3.28 ± 0.23	2.88 ± 0.37	2.76 ± 0.34
Kidneys
Absolute weight (g)	1.59 ± 0.15	1.49 ± 0.12	1.61 ± 0.13	1.63 ± 0.11	1.46 ± 0.12	1.60 ± 0.13
% body weight	0.74 ± 0.05	0.72 ± 0.06	0.75 ± 0.04	0.73 ± 0.03	0.67 ± 0.07	0.67 ± 0.11
Adrenal glands
Absolute weight (g)	0.07 ± 0.02	0.07 ± 0.01	0.06 ± 0.01	0.08 ± 0.01	0.07 ± 0.01	0.07 ± 0.01
% body weight	0.03 ± 0.01	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.03 ± 0.00
Heart
Absolute weight (g)	0.73 ± 0.05	0.67 ± 0.07	0.71 ± 0.03	0.71 ± 0.09	0.74 ± 0.02	0.73 ± 0.04
% body weight	0.34 ± 0.02	0.33 ± 0.02	0.33 ± 0.00	0.32 ± 0.03	0.34 ± 0.02	0.31 ± 0.04
Brain
Absolute weight (g)	1.84 ± 0.13	1.83 ± 0.11	1.81 ± 0.10	1.91 ± 0.05	1.89 ± 0.07	1.91 ± 0.10
% body weight	0.86 ± 0.03	0.89 ± 0.03	0.85 ± 0.02	0.86 ± 0.06	0.87 ± 0.06	0.80 ± 0.08
Spleen
Absolute weight (g)	0.48 ± 0.08	0.46 ± 0.05	0.48 ± 0.06	0.56 ± 0.08	0.45 ± 0.03	0.56 ± 0.08
% body weight	0.22 ± 0.03	0.22 ± 0.01	0.22 ± 0.02	0.25 ± 0.03	0.21 ± 0.02	0.23 ± 0.05
Thymus
Absolute weight (g)	0.41 ± 0.05	0.33 ± 0.07	0.36 ± 0.05	0.37 ± 0.03	0.30 ± 0.08	0.37 ± 0.06
% body weight	0.19 ± 0.03	0.16 ± 0.03	0.17 ± 0.02	0.17 ± 0.02	0.14 ± 0.04	0.16 ± 0.04
Uterus with CrV
Absolute weight (g)	0.45 ± 0.05	0.52 ± 0.11	0.41 ± 0.02	0.43 ± 0.12	0.59 ± 0.25	0.50 ± 0.21
% body weight	0.21 ± 0.02	0.25 ± 0.05	0.19 ± 0.01	0.19 ± 0.05	0.27 ± 0.11	0.21 ± 0.10
Ovaries
Absolute weight (g)	0.12 ± 0.02	0.10 ± 0.04	0.09 ± 0.01	0.10 ± 0.02	0.09 ± 0.01	0.09 ± 0.01
% body weight	0.05 ± 0.01	0.05 ± 0.01	0.04 ± 0.00	0.04 ± 0.01	0.04 ± 0.01	0.04 ± 0.01

vs. G1R n = 5; data are present as mean ± SD.