Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
Table 7
Effect of oral administration of GMCT on hematology parameters in male Wistar rats.
Parameters
Primary groups Dose (mg/kg/day)
Reversal groups Dose (mg/kg/day)
0 (G1)
250 (G2)
500 (G3)
1000 (G4)
0 (G1R)
1000 (G4R)
RBC (106/μL)
9.26 ± 0.22
9.01 ± 0.45
9.20 ± 0.58
9.46 ± 0.33
9.21 ± 0.24
9.46 ± 0.65
Hb (g/dL)
16.54 ± 0.23
16.00 ± 0.44
16.32 ± 0.87
16.62 ± 0.50
15.96 ± 0.50
16.28 ± 0.50
Hct (%)
50.68 ± 1.18
48.82 ± 1.35
49.60 ± 2.34
50.82 ± 0.73
49.38 ± 2.14
50.22 ± 2.60
MCV (fL)
54.70 ± 0.72
54.26 ± 1.51
53.96 ± 2.6
53.78 ± 1.41
53.56 ± 1.45
53.14 ± 1.43
MCH (pg)
17.88 ± 0.26
17.76 ± 0.53
17.78 ± 0.86
17.58 ± 0.36
17.32 ± 0.26
17.26 ± 0.73
MCHC (g/dL)
32.66 ± 0.32
32.70 ± 0.44
32.94 ± 0.65
32.7 ± 0.55
32.32 ± 0.37
32.5 ± 0.78
Plt (103/μL)
859.8 ± 39.8
859.60 ± 117.10
851.80 ± 50.60
817.4 ± 153.77
801.2 ± 134.29
817.6 ± 174.19
WBC (103/μL)
9.12 ± 0.86
8.97 ± 3.68
8.08 ± 1.71
7.2 ± 1.99
8.27 ± 0.78
7.27 ± 0.99
Neu (%)$
12.16 ± 0.76
23.06 ± 10.26
19.70 ± 5.01
15.2 ± 2.22
18.36 ± 3.61
16.76 ± 2.83
Lym (%)$
83.44 ± 1.63
71.44 ± 11.42
75.00 ± 5.56
80.66 ± 2.43
76.78 ± 3.71
78.06 ± 2.35
Mono (%)
2.10 ± 0.48
2.96 ± 0.81
2.72 ± 0.94
2.14 ± 0.59
2.64 ± 0.40
2.6 ± 0.91
Eos (%)
1.20 ± 0.46
1.22 ± 0.56
1.10 ± 0.44
1.04 ± 0.28
1.42 ± 0.77
1.56 ± 0.54
Baso (%)
0.42 ± 0.04
0.44 ± 0.23
0.36 ± 0.11
0.38 ± 0.18
0.38 ± 0.13
0.42 ± 0.11
LUC (%)
0.68 ± 0.11
0.90 ± 0.50
1.08 ± 0.48
0.56 ± 0.23
0.42 ± 0.13
0.58 ± 0.22
Rec (%)
2.40 ± 0.37
2.44 ± 0.36
2.34 ± 0.24
2.40 ± 0.40
2.32 ± 0.23
2.48 ± 0.23
CT (sec)
130.40 ± 18.7
146.6 ± 18.60
149.40 ± 20.31
134.00 ± 17.90
127.00 ± 10.42
142.6 ± 26.15
Data are present as mean ± SD; n = 5. Significance vs. G1. $The mean ± SD of the historical normal values of neutrophils (%) is 14.90 ± 3.69 (min. 8.20%; max. 30.20%) and lymphocytes (%) is 80.01 ± 4.31 (min. 63.0%; max. 87.80%).
