Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)
Table 9
Effect of oral administration of GMCT on biochemical parameters in male Wistar rats.
Parameters
Primary groups Dose (mg/kg/day)
Reversal groups Dose (mg/kg/day)
0 (G1)
250 (G2)
500 (G3)
1000 (G4)
0 (G1R)
1000 (G4R)
Glu (mg/dL)
150.40 ± 12.54
120.60 ± 14.57
144.40 ± 42.00
126.80 ± 12.28
132.00 ± 10.93
123.20 ± 10.10
BUN (mg/dL)
17.40 ± 2.41
18.40 ± 2.07
16.60 ± 4.16
20.20 ± 3.19
15.00 ± 1.00
15.40 ± 1.82
Ur (mg/dL)
37.60 ± 5.86
39.00 ± 4.12
35.60 ± 8.73
43.60 ± 7.09
32.00 ± 1.58
33.00 ± 3.87
Crea (mg/dL)
0.50 ± 0.03
0.48 ± 0.02
0.45 ± 0.05
0.49 ± 0.02
0.46 ± 0.05
0.47 ± 0.03
T.Chol (mg/dL)
53.40 ± 6.23
48.00 ± 3.67
52.40 ± 4.56
46.40 ± 7.27
53.20 ± 6.42
51.60 ± 13.07
Trig (mg/dL)
210 ± 82.5
173.4 ± 79.17
173.8 ± 88.3.5
161.00 ± 19.21
162.00 ± 44.23
154.40 ± 23.96
T.Bil (mg/dL)
0.04 ± 0.02
0.06 ± 0.04
0.04 ± 0.02
0.04 ± 0.02
0.12 ± 0.02
0.09 ± 0.03
AST (U/L)
88.20 ± 1.80
106.20 ± 18.86
88.20 ± 8.29
88.60 ± 8.80
99.60 ± 12.76
101.20 ± 13.65
ALT (U/L)
45.00 ± 2.92
53.60 ± 15.92
46.80 ± 14.24
61.60 ± 8.76
58.60 ± 6.54
55.80 ± 9.98
ALP (U/L)
109.00 ± 26.90
118.00 ± 16.87
103.00 ± 21.64
97.20 ± 12.70
85.40 ± 7.16
101.60 ± 16.23
TP (g/dL)$
6.88 ± 0.26
6.76 ± 0.15
6.46 ± 0.19
6.58 ± 0.26
6.86 ± 0.38
6.76 ± 0.09
Alb (g/dL)
4.06 ± 0.18
4.00 ± 0.12
3.94 ± 0.05
3.98 ± 0.25
3.96 ± 0.13
3.94 ± 0.05
Ca (mg/dL)
10.58 ± 0.15
10.38 ± 0.43
10.14 ± 0.15
10.14 ± 0.52
10.56 ± 0.28
10.22 ± 0.19
Phos (mg/dL)
6.90 ± 1.33
6.48 ± 0.81
6.32 ± 0.58
6.60 ± 0.67
6.50 ± 0.89
6.10 ± 0.64
Na (mmoL/L)
141.86 ± 0.40
141.38 ± 0.98
141.66 ± 0.81
142.44 ± 0.80
142.32 ± 0.87
142.14 ± 0.36
K (mmoL/L)
3.78 ± 0.18
3.82 ± 0.23
3.83 ± 0.17
3.74 ± 0.11
3.64 ± 0.12
3.86 ± 0.19
Cl (mmoL/L)
104.48 ± 0.77
104.10 ± 1.51
104.4 ± 1.11
104.28 ± 1.30
105.04 ± 1.62
104.96 ± 0.90
Data are present as mean ± SD; n = 5. Significance vs. G1. $The mean ± SD of the historical normal values total protein (TP) is 6.23 ± 0.33 g/dL (min. 5.50 g/dL; max. 6.90 g/dL).
