Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Figure 1

H&E-stained and Masson-stained kidney tissues of rats from different groups (magnification ×200). (a) Section of the control group showing the normal architecture of the kidney. (b) Significant increase in tubular dilatation and degenerative changes observed in HgCl₂-injured rats. (c) Treatment with DPPD significantly attenuated the renal histopathological changes. (d) Masson’s trichrome staining indicated no abnormal collagen in the control group. (e) Sections of HgCl₂-treated group indicated an increase in fibrosis stained in blue. (f) Kidney section of rats cotreated with HgCl₂ + DPPD showed a significant decrease in collagen deposits. (g) Pathological scoring showed a significant increase in the tubular injury score in the HgCl₂-treated group when compared with other groups. (h) Comparison between different groups in the Masson% area. Data were mean ± SD. vs. control; vs. HgCl₂.