Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Figure 2

H&E-stained and Masson-stained liver tissues of rats from different groups (magnification ×200). (a) Hepatic histology of the control group, showing normal hepatic lobular architecture. (b) Hepatic degenerative changes with extensive cell necrosis observed in HgCl₂-injured rats. (c) Rats treated with DPPD showed a significant modulation in the hepatic histology towards normal. (d) Control group stained with Masson’s trichrome showed that the natural structure and collagen fibers cannot be seen. (e) Accumulation and progression of collagen fibers in the liver of the HgCl₂ group. (f) Significant decrease in collagen fibers observed in rats cotreated with HgCl₂ + DPPD. (g) Pathological scoring showed a significant increase in the hepatic injury score in the HgCl₂-treated group compared with other groups. (h) Comparison between different groups in the Masson% area. Data were mean ± SD. vs. control; vs. HgCl₂.