Research Article
A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
Table 10
Summary of macroscopic results, 90-day study.
| Organs | Group‡ mg/kg bw/day | Control | 500 | 1000 | 2000 | Observations | (# with observation/# observed) |
| Males | No macroscopic findings | 8/10 | 6/10 | 9/10 | 5/10 | Thymus | Hemorrhage | 0/10 | 1/10 | 0/10 | 0/10 | Liver | Congestion | 0/10 | 0/10 | 0/10 | 1/10 | Kidneys | Cyst | 1/10 | 0/10 | 0/10 | 0/10 | Pyelectasia | 0/10 | 1/10 | 1/10 | 2/10 | Epididymides | Yellow knots on the tail | 0/10 | 1/10 | 0/10 | 0/10 | Spleen | Formation on the surface | 0/10 | 0/10 | 0/10 | 1/10 | Cecum | Dilatation | 0/10 | 0/10 | 0/10 | 1/10 | Skin | Alopecia | 1/10 | 1/10 | 0/10 | 0/10 |
| Females | No macroscopic findings | 2/10 | 7/10 | 5/10 | 8/10 | Lungs | Point-like hemorrhages | 1/10 | 0/10 | 0/10 | 0/10 | Kidneys | Pyelectasia | 2/10 | 1/10 | 0/10 | 0/10 | Hydronephrosis | 1/10 | 0/10 | 0/10 | 0/10 | Ureter | Dilatation | 1/10 | 0/10 | 0/10 | 0/10 | Thymus | Hemorrhages | 1/10 | 0/10 | 1/10 | 2/10 | Uterus | Hydrometra | 6/10 | 3/10 | 5/10 | 0/10 | Skin | Alopecia | 1/10 | 0/10 | 0/10 | 0/10 |
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‡n = 10 for all groups.
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