A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
Table 11
Summary of relevanta absolute and relative organ weights.
Organ weight (g)
Organ weight relative to body weight (%)
Organ weight relative to brain and body weights (%)
Group‡ mg/kg bw/day
Body weight
Heart
Testes/uterus
Brain
Liver
Kidneys
Heart
Testes/uterus
Adrenals
Liver
Males
Control
Mean
453.90
1.03
3.69
0.488
2.918
0.558
0.228
0.813
0.013
599.45
SD
37.20
0.10
0.36
0.033
0.177
0.041
0.015
0.061
0.002
31.07
500
Mean
449.4
1.07
3.60
0.486
2.872
0.557
0.239
0.800
0.014
591.18
SD
26.28
0.06
0.25
0.022
0.215
0.026
0.013
0.039
0.002
37.77
1000
Mean
435.8
1.07
3.53
0.491
2.883
0.576
0.245
0.813
0.014
591.36
SD
52.01
0.13
0.47
0.047
0.255
0.036
0.008
0.083
0.003
73.56
SS
2000
Mean
408.3
0.93
3.60
0.521
2.984
0.609
0.229
0.884
0.016
574.29
SD
29.98
0.08
0.21
0.034
0.255
0.055
0.015
0.062
0.003
59.66
SS
Test for significance
DN
DN
NS
DN
NS
DN
DN
DN
DN
NS
Historical control range
344–488
0.97–1.50
2.58–4.20
0.441–0.599
1.916–3.108
0.466–0.650
0.216–0.311
0.642–1.011
0.012–0.023
371.50–660.20
Females
Control
Mean
239.3
0.72
0.77
0.825
2.659
0.659
0.301
0.322
0.0331
324.64
SD
15.83
0.07
0.16
0.066
0.148
0.106
0.022
0.073
0.0042
34.68
500
Mean
242.0
0.70
0.67
0.812
2.881
0.642
0.290
0.281
0.0345
357.26
SD
16.19
0.08
0.14
0.070
0.318
0.065
0.030
0.071
0.0046
48.82
SS
1000
Mean
234.3
0.68
0.67
0.826
2.749
0.648
0.289
0.287
0.0328
333.21
SD
11.29
0.03
0.16
0.048
0.173
0.030
0.018
0.075
0.0043
22.17
2000
Mean
236.8
0.69
0.57
0.803
2.883
0.660
0.290
0.243
0.0321
360.17
SD
17.61
0.06
0.11
0.060
0.176
0.046
0.018
0.050
0.0027
28.19
SS
Test for significance
NS
NS
DN
NS
DN
NS
NS
DN
NS
DN
Historical control range
206–285
0.66–0.96
0.40–2.07
0.681–0.943
2.172–3.214
0.530–0.752
0.273–0.396
0.167–0.852
0.026–0.044
276.04–412.95
Abbreviations: DN: Duncan’s multiple range test; SD: standard deviation; SS: statistical significance; NS: nonsignificant; a Only statistically significant findings are shown. ‡n = 10 for all groups. ,.
