The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

Table 2

Prenatal development of progeny F1.

Indicators		Group				Historical control data
		Control		Test
		Control-19	Control-75	Test-19	Test-75
Number of pregnant females		8	7	5	9	—
Number of ovarian corpora-lutea	Total	119	112	65	132	5–23
	M ± m	14.88 ± 0.67	16.00 ± 0.82	13.00 ± 1.95	14.67 ± 0.82
	min–max	13–19	13–19	6–18	10–18
Number of implantation sites	Total	100	101	53	101	3–18
	M ± m	12.50 ± 0.73	14.43 ± 0.81	10.60 ± 2.52	11.22 ± 1.75
	min–max	9–15	11–17	2–17	2–17
Number of alive fetuses	Total	69	89	12	95	2–18
	M ± m	8.63 ± 1.36	12.71 ± 0.97	2.4 ± 1.69	10.56 ± 1.72
	min–max	1–14	7–14	0–9	1–16
Number of resorptions	Total	30	12	41	6	0–10
	M ± m	3.75 ± 1.36	1.71 ± 0.61	8.20 ± 2.85	0.67 ± 0.37
	min–max	0–12	0–4	1–15	0–3
Number of dead fetuses		2	0	1	0	—
Preimplantation loss
%	M ± m	15.23 ± 5.39	9.74 ± 2.72	24.77 ± 11.74	24.11 ± 11.21	15 ± 1
	min–max	0–37	0–22	0–67	0–83	0–80
Absolute value	Total	19	11	12	31	2.2 ± 0.2
	M ± m	2.38 ± 0.91	1.57 ± 0.48	2.40 ± 0.81	3.44 ± 1.68
	min-max	0–7	0–4	0–4	0–15	0–13
Postimplantation loss
%	M ± m	30.64 ± 10.41	12.21 ± 4.87	78.22 ± 17.20	9.37 ± 5.65	7 ± 1
	min–max	0–93	0–36	10–100	0–50	0–100
Absolute value	Total	32	12	41	6	0.8 ± 0.1
	M ± m	4.00 ± 1.46	1.71 ± 0.61	8.20 ± 2.85	0.67 ± 0.37
	min–max	0–13	0–4	1–15	0–3	0–10

Significant differences compared to the appropriate control (, ANOVA, Student’s t-test).