The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo

Table 3

Postnatal development of progeny F1.

Indicators		Group
		Control		Test
		Control-19	Control-75	Test-19	Test-75
Number of pregnant females		21	23	8	24
Number of females giving birth to a litter		21	23	6	24
Number of litters killed by mothers on the 1st day of life		0	0	4	1
Total number of pups		168	252	9	255
Of those—stillborn		17	3	0	7
Mean litter size	M ± m	6.88 ± 1.64	10.83 ± 0.87	4.50 ± 2.50	10.78 ± 0.63
	min–max	2–14	3–19	2–7	3–16

In 2 females, the pregnancy was diagnosed based on the dynamics of body weight (increase of more than 70 g in 20 days), facts of delivery were not registered, and there were no pups in the cages (probably killed by mothers after birth). It is impossible to estimate since the facts of delivery were not registered.