Subacute Hepatotoxicity of Extracts of Senna occidentalis Seeds in Swiss Albino Mice

Figure 2

Photomicrographs of liver sections (H & E stain, X400) illustrating hepatocytes (H), central vein (CV), sinusoids (S), endothelial cells (E), kupffer cells (KC), portal vein (PV), and hepatic artery (HA). (a, b) depict liver sections of control mice showing normal architecture of liver with intact hepatic lobules and portal tract, (c) depicts liver sections of mice treated with 400 mg/kg extract of S. occidentalis showing moderate microvesicular steatosis of hepatocytes diffusely (yellow arrow) and mild inflammation (red), (d) depicts liver sections of mice treated with 1000 mg/kg extract of S. occidentalis showing marked micro- and macrovesicular steatosis (yellow arrow) and focal area necrosis (normal arrow), and (e) depicts liver sections periportal inflammation with mononuclear cell infiltration (normal arrow).