Subacute Hepatotoxicity of Extracts of Senna occidentalis Seeds in Swiss Albino Mice

Table 2

Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after 28-day treatment of Senna occidentalis seed extract as compared to control.

Biomarkers	Control	400 mg/kg	1000 mg/kg
ALT	23.7 ± 3.85	36.2 ± 1.25 (0.045)	59 ± 13.1 (0.016)
ALT-fold increase	1.00	1.53	2.49
AST	93.4 ± 8.85	246.2 ± 50.45 (0.013)	295.8 ± 26.16 (0.002)
AST-fold increase	1.00	2.64	3.17

Data are presented as mean ± SEM. Statistical significance is shown in parenthesis and asterisks show significant difference from the control: ; .