Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Table 10

Effect of 50–400 mg/kg/day of CVE on the serum lipid profile of DOX-treated rats.

Groups	Serum lipids
	TG (mmol/l)	TC (mmol/l)	HDL-c (mmol/l)	LDL-c (mmol/l)	VLDC-c (mmol/l)
I	1.3 ± 0.1^c+	2.3 ± 0.1^a+	0.6 ± 0.0	1.2 ± 0.1	1.3 ± 0.1^c+
II	0.8 ± 0.2^d−	1.8 ± 0.2^d−	0.6 ± 0.0	0.9 ± 0.1^d−	0.4 ± 0.1^f−
III	0.8 ± 0.1^d−	2.3 ± 0.1	0.7 ± 0.0	1.3 ± 0.1	0.5 ± 0.1^f−
IV	1.1 ± 0.1	2.3 ± 0.1	0.6 ± 0.0	1.2 ± 0.1	0.5 ± 0.1^f−
V	0.8 ± 0.1^d−	2.3 ± 0.1	0.6 ± 0.0	1.3 ± 0.1	0.4 ± 0.0^f−
VI	1.0 ± 0.1^d−	2.3 ± 0.2	0.6 ± 0.0	1.2 ± 0.1	0.5 ± 0.1^f−
VII	0.9 ± 0.1^d−	2.1 ± 0.1	0.6 ± 0.0	1.1 ± 0.1	0.4 ± 0.0^f−
VIII	0.6 ± 0.1	2.0 ± 0.1	0.6 ± 0.0	1.1 ± 0.0	0.3 ± 0.0

^a+,c+Significant increases at and , respectively, when compared to the untreated negative (normal) control value. ^d−,f−Significant decreases at and when compared to the untreated positive (doxorubicin treated only) control values, respectively.