Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Table 11

Effect of 50–400 mg/kg/day of CVE on the atherogenic index (AI) and the coronary artery index (CRI) in DOX-intoxicated rats.

Treatment groups	AI	CRI
I	2.1 ± 0.1	4.0 ± 0.2^a+
II	1.6 ± 0.2	3.2 ± 0.2^e−
III	2.0 ± 0.2	3.5 ± 0.2^d−
IV	1.9 ± 0.3	3.9 ± 0.3
V	2.1 ± 0.1	3.8 ± 0.1^d−
VI	2.0 ± 0.1	3.8 ± 0.2^d−
VII	1.8 ± 0.1	3.8 ± 0.2^d−
VIII	1.1 ± 0.0	3.5 ± 0.1

^a+A significant increase at when compared to the untreated negative (normal) control values. ^d−,e−Significant decreases at and , respectively, when compared to the untreated positive (doxorubicin treated only) control values, respectively.