Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats

Table 8

Antioxidant activities of 50–400 mg/kg/day of CVE in DOX-treated rat cardiac tissue.

Groups	Antioxidant parameters
	GSH	GST	GPx	SOD	CAT	MDA
I	88.1 ± 5.3^c−	20.4 ± 0.1^c−	81.7 ± 4.9^c−	2.0 ± 0.2^a−	13.3 ± 1.7^a−	2.8 ± 0.1
II	62.8 ± 4.9^f−	21.4 ± 0.9^f−	69.4 ± 5.4	2.2 ± 0.1	11.3 ± 0.5	2.1 ± 0.3
III	51.2 ± 2.8^c−	20.8 ± 0.3^f−	51.5 ± 3.1^f−	3.3 ± 0.2	17.9 ± 1.1	3.5 ± 0.4
IV	77.6 ± 5.7	30.8 ± 0.7^c+	81.4 ± 5.4	5.5 ± 1.1^c+	35.6 ± 4.1^c+	4.3 ± 0.3^b+
V	45.6 ± 4.2^c−	21.5 ± 0.4^f−	50.3 ± 4.6^f−	4.0 ± 0.2^a+	21.8 ± 1.6^a+	3.9 ± 0.2^a+
VI	65.7 ± 4.3^c−	22.3 ± 0.8^f−	64.6 ± 4.0^d−	2.8 ± 0.3	19.6 ± 0.7	6.4 ± 0.7^c+
VII	112.6 ± 2.3^c+	21.9 ± 0.3^f−	111.1 ± 2.3^c+	5.3 ± 0.2^c+	40.2 ± 1.7^c+	4.5 ± 0.5^b+
VIII	113.5 ± 2.2	23.6 ± 0.4	111.9 ± 2.2	2.5 ± 0.2	19.8 ± 1.5	2.4 ± 0.2

^a−,c−Significant decreases at and , respectively, when compared to the untreated negative (normal) control value. ^c+A significant increase at when compared to the untreated negative (normal) control values. ^a+,b+Significant increases at and , respectively, when compared to the untreated negative (normal) control values. ^d−,f−Significant decreases at and when compared to the untreated positive (doxorubicin treated only) control values, respectively.