Evaluation of 1-Propanol Toxicity in B6C3F1 Mice via Repeated Inhalation over 28 and 90 Days

Table 3

Blood chemistry from B6C3F1 mice exposed to inhaled 1-propanol over 90 days.

Parameters	Control (0 ppm)	T1 (500 ppm)	T2 (1600 ppm)	T3 (5200 ppm)
Male
ALT (IU/L)	33.32 ± 12.36	29.95 ± 4.26	28.82 ± 7.34	31.96 ± 10.84
AST (IU/L)	50.91 ± 19.12	44.84 ± 4.71	44.17 ± 8.32	46.89 ± 8.35
ALP (IU/L)	234.01 ± 24.7	217.47 ± 16.2	222.26 ± 11.4	220.29 ± 14.8
TP (g/dL)	4.92 ± 0.123	4.97 ± 0.250	5.02 ± 0.193	5.05 ± 0.178
ALB (g/dL)	2.98 ± 0.063	3.01 ± 0.120	1.56 ± 0.052	1.58 ± 0.063
GLU (mg/dL)	240.35 ± 42.4	235.47 ± 30.4	244.39 ± 21.3	245.47 ± 35.9
TG (mg/dL)	70.03 ± 66.24	43.67 ± 16.69	46.71 ± 16.48	50.02 ± 25.23
TCHO (mg/dL)	139.37 ± 13.6	139.55 ± 15.1	134.57 ± 12.7	139.94 ± 8.2
TBIL (mg/dL)	0.166 ± 0.041	0.202 ± 0.044	0.186 ± 0.034	0.182 ± 0.041
BUN (mg/dL)	31.70 ± 5.866	30.25 ± 3.729	32.01 ± 6.368	32.09 ± 6.110
CREA (mg/dL)	0.360 ± 0.032	0.356 ± 0.030	0.376 ± 0.042	0.355 ± 0.034
Na (mmol/L)	135.18 ± 1.62	135.40 ± 1.51	135.84 ± 1.66	135.90 ± 1.08
Cl (mmol/L)	103.12 ± 1.26	104.20 ± 1.80	103.68 ± 1.83	104.20 ± 0.99
K (mmol/L)	4.670 ± 0.236	4.930 ± 0.395	4.860 ± 0.406	5.150 ± 0.467
Ca (mg/dL)	9.36 ± 0.212	9.39 ± 0.292	9.43 ± 0.231	9.35 ± 0.232
IP (mg/dL)	8.79 ± 1.260	9.04 ± 1.622	9.55 ± 1.386	8.54 ± 0.914
Female
ALT (IU/L)	31.14 ± 9.105	28.17 ± 7.746	27.59 ± 2.836	29.50 ± 11.27
AST (IU/L)	60.39 ± 14.58	53.55 ± 7.38	52.76 ± 6.65	54.87 ± 14.39
ALP (IU/L)	364.17 ± 35.9	352.87 ± 46.7	353.42 ± 29.0	352.19 ± 36.1
TP (g/dL)	5.13 ± 0.263	5.13 ± 0.216	5.17 ± 0.177	5.18 ± 0.114
ALB (g/dL)	3.22 ± 0.123	3.27 ± 0.149	3.26 ± 0.107	3.25 ± 0.071
GLU (mg/dL)	272.52 ± 38.6	256.64 ± 36.3	253.26 ± 70.0	281.99 ± 35.5
TG (mg/dL)	29.26 ± 6.966	31.61 ± 13.24	29.75 ± 8.641	31.27 ± 15.08
TCHO (mg/dL)	115.63 ± 8.51	115.36 ± 6.85	116.93 ± 7.07	119.82 ± 12.26
TBIL (mg/dL)	0.169 ± 0.015	0.166 ± 0.026	0.145 ± 0.041	0.184 ± 0.054
BUN (mg/dL)	23.35 ± 4.359	21.94 ± 1.914	21.39 ± 2.328	24.00 ± 1.683
CREA (mg/dL)	0.367 ± 0.049	0.357 ± 0.039	0.347 ± 0.038	0.363 ± 0.221
Na (mmol/L)	137.05 ± 3.25	136.06 ± 1.40	136.46 ± 1.62	136.41 ± 0.76
Cl (mmol/L)	106.21 ± 3.08	105.02 ± 1.70	105.23 ± 1.82	105.78 ± 1.22
K (mmol/L)	4.680 ± 0.707	4.850 ± 0.572	5.030 ± 0.807	4.820 ± 0.733
Ca (mg/dL)	9.62 ± 0.253	9.43 ± 0.275	9.64 ± 0.401	9.58 ± 0.274
IP (mg/dL)	9.28 ± 0.913	8.99 ± 1.159	9.40 ± 1.445	9.00 ± 1.378

Values are expressed as mean ± SD. ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TP, total protein; ALB, albumin; GLU, globulin; TG, Triglyceride; TCHO, total cholesterol; TBIL, total bilirubin; BUN, blood urea nitrogen; CREA, creatinine; Na, sodium; Cl, chloride; K, potassium; Ca, calcium; IP, inorganic phosphorus.