Evaluation of 1-Propanol Toxicity in B6C3F1 Mice via Repeated Inhalation over 28 and 90 Days

Table 4

Absolute organ weights of B6C3F1 mice exposed to inhaled 1-propanol over 90 days.

Parameters	Control (0 ppm)	T1 (500 ppm)	T2 (1600 ppm)	T3 (5200 ppm)
Male
Adrenal glands	0.005 ± 0.002	0.005 ± 0.001	0.005 ± 0.001	0.005 ± 0.001
Brain	0.473 ± 0.008	0.464 ± 0.010	0.473 ± 0.012	0.466 ± 0.017
Epididymis	0.095 ± 0.011	0.106 ± 0.013	0.098 ± 0.006	0.101 ± 0.011
Heart	0.143 ± 0.014	0.145 ± 0.010	0.142 ± 0.014	0.142 ± 0.010
Kidneys	0.432 ± 0.057	0.440 ± 0.032	0.455 ± 0.027	0.456 ± 0.025
Liver	1.311 ± 0.183	1.262 ± 0.088	1.313 ± 0.159	1.269 ± 0.152
Lung	0.157 ± 0.016	0.159 ± 0.015	0.161 ± 0.009	0.158 ± 0.014
Spleen	0.070 ± 0.016	0.071 ± 0.007	0.074 ± 0.004	0.073 ± 0.009
Testes	0.226 ± 0.016	0.226 ± 0.012	0.222 ± 0.013	0.225 ± 0.018
Thymus	0.035 ± 0.010	0.040 ± 0.005	0.036 ± 0.005	0.035 ± 0.006
Female
Adrenal glands	0.007 ± 0.003	0.008 ± 0.002	0.008 ± 0.003	0.009 ± 0.002
Brain	0.485 ± 0.014	0.483 ± 0.010	0.482 ± 0.019	0.473 ± 0.010
Heart	0.120 ± 0.009	0.112 ± 0.008	0.124 ± 0.010	0.119 ± 0.006
Kidneys	0.301 ± 0.017	0.286 ± 0.021	0.299 ± 0.022	0.307 ± 0.019
Liver	1.070 ± 0.099	1.100 ± 0.127	1.079 ± 0.115	1.107 ± 0.084
Lung	0.163 ± 0.016	0.150 ± 0.014	0.151 ± 0.014	0.157 ± 0.010
Ovaries	0.011 ± 0.004	0.012 ± 0.002	0.014 ± 0.007	0.014 ± 0.003
Spleen	0.089 ± 0.009	0.078 ± 0.007	0.089 ± 0.011	0.091 ± 0.008
Thymus	0.043 ± 0.007	0.037 ± 0.009	0.043 ± 0.010	0.045 ± 0.007
Uterus	0.156 ± 0.038	0.117 ± 0.046	0.152 ± 0.047	0.131 ± 0.034