Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Table 2

Effect of RC extract on oxidative stress markers in VAN-treated rat serum.

Groups	MDA (nmol/L)	NO metabolite (μmol/L)
Control	2.57 ± 0.22	12.74 ± 0.29
VAN	4.03 ± 0.06	28.95 ± 1.58
VAN + RC 250 mg/kg	2.68 ± 0.12^#	23.80 ± 0.99
VAN + RC 500 mg/kg	2.62 ± 0.09^#	17.20 ± 0.48^#
RC 500 mg/kg	2.74 ± 0.20	14.27 ± 0.22

NO, nitric oxide metabolites; MDA, malondialdehyde; VAN, vancomycin; RC, Rosa canina. Each value represents the mean ± SEM. Statistically significant compared to the control group (); ^#statistically significant compared to the VAN group ().