Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Table 3

Histopathological alteration scoring of renal tissue in experimental groups.

Histological parameters	Control	VAN	VAN + RC 250 mg/kg	VAN + RC 500 mg/kg	RC 500 mg/kg
Tubular epithelial necrosis	_	++	+	_	_
Vacuolization	_	+++	_	_	_
Tubular dilatation	_	+++	++	+	_
Tubular casts	_	++	+	+	_
Interstitial inflammation	_	+++	+	_	-
Interstitial edema	_	++	+	_	_
Dilatation of Bowman’s space	_	+	_	_	_
Total histological score	0 ± 0	2.28 ± 0.28	0.85 ± 0.26^#	0.28 ± 0.18^#	0 ± 0^#

VAN, vancomycin; RC, Rosa canina. Each value represents the group score mean. Statistically significant compared to the control group (); ^#statistically significant compared to the VAN group ().