Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models

Table 1

The mean values of survival time for each group of male and female rats during the experiment.

Group	n	Group name	Number of death animals (male)						Survived	Survival time (day)	Group	n	Number of death animals (female)						Survived	Survival time (day)	PWilcoxon
		Day	1	2	3	4	5	6					1	2	3	4	5	6
1	6	NS + CP + NS	—	—	—	—	—	—	6	7.0 ± 0.0	8	6	—	—	—	—	—	—	6	7.0 ± 0.0	1.0
2	6	M + CP + M	—	—	—	—	—	3	3	6.5 ± 0.2^a,b	9	6	—	—	—	—	—	5	1	6.2 ± 0.2^a,b	0.4
3	6	DS + CP + DS	—	—	—	—	—	—	6	7.0 ± 0.0	10	6	—	—	—	—	—	4	2	6.3 ± 0.2^a,b	0.06
4	6	NS + CP + NS,F	—	—	—	—	—	1	5	6.8 ± 0.2	11	6	—	—	—	—	—	—	6	7.0 ± 0.0	0.7
5	6	M, NS + CP + NS	—	—	—	—	—	—	6	7.0 ± 0.0	12	6	—	—	—	—	—	1	5	6.8 ± 0.2	0.7
6	6	CP	—	—	—	—	—	—	6	7.0 ± 0.0	13	6	—	—	—	—	—	1	5	6.8 ± 0.2	0.7
7	4	NS	—	—	—	—	—	—	4	7.0 ± 0.0	14	4	—	—	—	—	—	—	4	7.0 ± 0.0	1.0
PKruskal–Wallis H										0.033	PKruskal–Wallis H									0.002

The small alphabetic letters indicate a significant difference from (a) NS and (b) CP (). Each two groups of male and female that received a similar hydration protocol was compared using Mann–Whitney U analysis. Refer the text for group treatment. The comparison of survival time between each sex was performed using the Wilcoxon test.