Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models
Table 2
The effect of cisplatin (CP).
Parameter/group
Male
Female
NS
CP
P
NS
CP
P
BUN (mg/dl)
24.0 ± 0.4
128.4 ± 42.6
0.06
21.2 ± 1.2
146.0 ± 49.2
0.04
Cr (mg/dl)
0.4 ± 0.0
1.4 ± 0.4
0.09
0.57 ± 0.0
1.5 ± 0.4
0.05
KW (g/100 g BW)
0.7 ± 0.1
1.3 ± 0.0
0.01
0.6 ± 0.0
1.0 ± 0.0
<0.0001
BW(% change)
3.8 ± 2.0
−23.3 ± 2.5
<0.0001
11.5 ± 1.1
−22.8 ± 1.7
<0.0001
KTDS
0.5 ± 0.2
3.5 ± 0.2
0.02
0.2 ± 0.2
3.4 ± 0.6
0.01
UF (μl/min g kW)
5.5 ± 2.1
6.0 ± 1.1
0.85
6.9 ± 2.0
8.8 ± 1.8
0.52
ClCr (μl/min g kW)
530.1 ± 153.0
109.5 ± 34.0
0.03
334.5 ± 69.2
125.9 ± 28.0
0.03
ENa (%)
1.0 ± 0.2
2.6 ± 1.3
0.29
0.91 ± 0.24
1.0 ± 0.3
0.78
SNitrite (μmol/L)
10.52 ± 1.2
13.37 ± 3.6
0.52
10.28 ± 1.4
24.58 ± 3.7
0.01
SMDA(μmol/L)
4.9 ± 0.1
3.2 ± 0.2
<0.0001
3.8 ± 0.24
4.1 ± 0.15
0.35
KNitrite (μmol/g tissue)
182.6 ± 4.2
148.0 ± 9.0
0.01
187.6 ± 19.7
103 ± 7.0
<0.0001
KMDA (nmol/g tissue)
64.2 ± 2.7
29.1 ± 1.2
<0.0001
65.9 ± 4.1
58.1 ± 11.8
0.55
values are obtained by the t-Student test. BUN, blood urea nitrogen; Cr, creatinine; KW, kidney weight; BW, bodyweight; KTDS, kidney tissue damage score; UF, urine flow rate; ClCr, clearance of Cr, ENa%, excretion fraction of sodium; SMDA and KMDA, serum and kidney levels of malondialdehyde; serum and kidney levels of nitrite in normal saline (NS) and CP-treated groups of male and female rats.
