Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models
Table 3
Serum and kidney levels of nitrite and MDA in both male and female rats treated with different hydration protocols.
Group/parameter
Male
Female
Snitrite (μmol/l)
SMDA (μmol/l)
Knitrite (μmol/g tissue)
KMDA (nmol/g tissue
Snitrite (μmol/l)
SMDA (μmol/l)
Knitrite (μmol/g tissue)
KMDA (nmol/g tissue
NS + CP + NS
10.4 ± 1.1
3.1 ± 0.2
89.5 ± 11.9
21.7 ± 4.5
36.7 ± 5.4
1.1 ± 0.2
106.0 ± 6.3
26.7 ± 3.0
M + CP + M
16.3 ± 5.3
2.2 ± 0.2
90.8± ± 15.7
28.2 ± 6.2
—
—
—
—
DS + CP + DS
22.1 ± 6.5
2.8 ± 0.6
122.2 ± 8.1
24.4 ± 3.8
—
—
—
—
NS + CP + NS, F
10.2 ± 1.6
2.6 ± 0.4
123.3 ± 9.5
38.3 ± 2.2
37.5 ± 12.5
2.5 ± 0.4
130.2 ± 14.8
41.1 ± 9.9
M, NS + CP + NS
14.5 ± 3.5
3.3 ± 0.1
152.1 ± 4.8
49.0 ± 6.3
36.4 ± 21.2
4.7 ± 0.9
109.9 ± 7.9
49.5 ± 19.4
CP
13.4 ± 3.6
3.3 ± 0.2
148.0 ± 9.1
29.2 ± 1.2
24.6 ± 3.8
4.1 ± 0.2
103.7 ± 7.0
58.1 ± 11.8
Significant difference from CP () obtained by the t-Student test.
