Effect of Azadirachta indica and Senna siamea Decoction on CD4+ and CD8+ Level, Toxicological, and Antioxidant Profile in HIV/AIDS Positive Persons

Table 4

Variation of biochemical parameters in different groups.

Time	Parameters	Group 1; N  = 97	Group 2; N  = 100	Group 3; N  = 100	value
Day 0	ALT (UI/L)	37 ± 9	35 ± 12	40 ± 8	0.123
	AST (UI/L)	34 ± 8	39 ± 9	36 ± 7	0.280
	ALP (UI/L)	94 ± 14	102 ± 17	89 ± 12	0.178
	BUN (mmol/L)	10 ± 3	10 ± 4	9 ± 3	0.523
	Creatinine (μmol/L)	77 ± 12	74 ± 10	80 ± 17	0.347
	CAT (U/mg protein)	0.407 ± 0.103	0.367 ± 0.120	0.480 ± 0.103	0.157
	SOD (U/mg protein)	10.14 ± 3.20	11.96 ± 2.36	10.58 ± 3.34	0.309
	GSH (μmol/mL)	16.55 ± 5.13	16.57 ± 5.39	18.82 ± 5.74	0.291
After 30 days	ALT (UI/L)	30 ± 10	55 ± 16	46 ± 9	0.214
	AST (UI/L)	29 ± 5^a	54 ± 14^b	34 ± 6^a	0.04
	ALP (UI/L)	100 ± 27^a	230 ± 71^b	94 ± 13^a	0.01
	BUN (mmol/L)	10 ± 2	16 ± 5	10 ± 4	0.127
	Creatinine (μmol/L)	82 ± 19	110 ± 28	71 ± 16	0.08
	CAT (U/mg protein)	0.615 ± 0.106^c	0.247 ± 0.113^a	0.510 ± 0.124^b	0.01
	SOD (U/mg protein)	11.10 ± 3.07	20.96 ± 7.15	16.34 ± 4.07	0.06
	GSH (μmol/mL)	36.75 ± 6.24^b	10.57 ± 3.14^a	24.80 ± 5.40^b	0.03
After 3 months	ALT (UI/L)	33 ± 6^a	91 ± 23^b	42 ± 8^a	0.03
	AST (UI/L)	36 ± 10^a	84 ± 27^b	36 ± 4^a	0.01
	ALP (UI/L)	108 ± 35^a	327 ± 101^b	100 ± 16^a	0.01
	BUN (mmol/L)	8 ± 3^a	27 ± 9^b	10 ± 4^a	0.04
	Creatinine (μmol/L)	79 ± 17	114 ± 41	76 ± 14	0.07
	CAT (U/mg protein)	0.679 ± 0.121^b	0.252 ± 0.109^a	0.564 ± 0.119^b	0.01
	SOD (U/mg protein)	15.50 ± 3.43^a	38.76 ± 13.23^b	17.86 ± 4.12^a	0.03
	GSH (μmol/mL)	34.39 ± 8.40^b	12.80 ± 4.12^a	47.63 ± 10.02^b	0.01

Group 1, decoction; Group 2, ART; Group 3, ART + decoction. AST, aspartate transaminase; ALT, alanine transaminase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; CAT, catalase; SOD, superoxide dismutase. Results are in means ± SEM; a, b, and c indicate statistical differences of Tukey’ posthoc test; statistically significant (, one-way ANOVA of groups 1, 2, and 3).