Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential
Table 1
Experimental design of reproductive toxicology.
Group
Number of animals
Notes
Females
Males
“Experiment 1”: reproductive function of females
Cocoa HD
20
10
Female rats were orally administered UNCP at HD and LD for 15 days (duration of three oestrous cycles) before mating. Control animals received an equivalent volume of the vehicle (starch suspension) at the same time
Cocoa TD
20
10
Control (solvent)
20
10
“Experiment 2”: reproductive function of males
Cocoa HD
20
10
Male rats were orally administered UNCP at HD and LD for 48 days (duration of one cycle of spermatogenesis) before mating. Control animals received an equivalent volume of the vehicle (starch suspension) at the same time
