Journal of Toxicology

Research Article

Toxicological Profile of the Aqueous Extract of Tectona grandis L.F. (Verbenaceae) Leaves: A Medicinal Plant Used in the Treatment of Typhoid Fever in Traditional Cameroonian Medicine

Table 4

Effect of aqueous extract of T. grandis leaves on hematological parameters of animals.


Groups	RBCs (×10⁶/μL)	HGB (g/dL)	HCT (%)	WBCs (×10³/μL)	LYM (%)	MID (%)	GRAN (%)	PLT (10³/μL)

Males
Control	8.60 ± 0.41a	16.83 ± 0.55b	50.97 ± 1.69b	12.30 ± 0.96^a	69.70 ± 9.19^a	9.47 ± 3.74^a	20.83 ± 5.46^a	527.00 ± 101.95^a
30 mg/kg	8.32 ± 0.53a	16.57 ± 0.95b	52.20 ± 3.92b	13.57 ± 1.42^a	67.67 ± 0.74^a	14.23 ± 0.50^a	18.10 ± 1.21^a	537.33 ± 133.72^a
90 mg/kg	7.80 ± 0.19a	15.10 ± 0.36a	46.40 ± 2.76ab	13.07 ± 2.45^a	65.37 ± 10.61^a	10.53 ± 3.16^a	24.10 ± 7.45^a	438.33 ± 112.72^a
270 mg/kg	7.98 ± 0.48a	15.00 ± 0.44a	43.83 ± 4.37a	13.10 ± 2.81^a	61.17 ± 7.43^a	13.57 ± 2.12^a	25.27 ± 5.84^a	486.67 ± 64.76^a
810 mg/kg	8.23 ± 0.38a	16.00 ± 0.36ab	47.93 ± 2.41 ab	13.13 ± 0.75^a	60.97 ± 4.00^a	12.43 ± 0.50^a	26.60 ± 3.50^a	565.67 ± 47.61^a

Females
Control	7.67 ± 0.49^a	15.57 ± 0.85^a	47,40 ± 3,58^a	9.43 ± 1.58^a	66.77 ± 3.58^a	12.37 ± 0.38^a	20.87 ± 3.95^a	551.00 ± 124.83^a
30 mg/kg	7.83 ± 0.88^a	15.60 ± 0.95^a	48.37 ± 6.68^a	12.20 ± 4.33^a	75.87 ± 6.36^a	10.70 ± 1.30^a	16.43 ± 5.49^a	467.67 ± 58.05^a
90 mg/kg	7.88 ± 0.45^a	15.60 ± 0.46^a	46.90 ± 1.84^a	11.03 ± 1.76^a	69.40 ± 4.16^a	10.40 ± 0.44^a	20.20 ± 3.84^a	549.00 ± 62.43^a
270 mg/kg	8.08 ± 1.06^a	15.53 ± 0.76^a	47.77 ± 5.76^a	11.33 ± 1.19^a	72.60 ± 7.67^a	10.57 ± 3.61^a	16.83 ± 5.44^a	653.00 ± 133.41^a
810 mg/kg	7.84 ± 0.43^a	15.43 ± 1.24^a	47.70 ± 3.20^a	11.80 ± 0.96^a	69.80 ± 1.40^a	11.70 ± 2.59^a	18.50 ± 3.30^a	740.67 ± 219.72^a

Data are expressed as mean ± SD, n = 4. Values for a given group in a column followed by a different letter as superscript are significantly different according to Waller–Duncan’s multiple comparison test ( < 0.05). RBCs: red blood cells; HGB: hemoglobin; LYM: lymphocytes; MID: mean corpuscular volume; GRAN: granulocytes; WBCs: white blood cells; PLT: platelets; HCT: hematocrit.