Toxicological Profile of the Aqueous Extract of Tectona grandis L.F. (Verbenaceae) Leaves: A Medicinal Plant Used in the Treatment of Typhoid Fever in Traditional Cameroonian Medicine

Table 5

Effect of aqueous extract of T. grandis leaves on liver function markers of animals.

Groups	ALT (U/L)	AST (U/L)	ALP (U/L)	Serum protein (mg/dL)
Males
Control	354.15 ± 18.88^e	30.41 ± 7.09^a	130.35 ± 14.00^c	6.73 ± 1.02^b
30 mg/kg	227.93 ± 17.99^d	30.63 ± 4.35^a	122.51 ± 14.96^bc	6.20 ± 1.54^b
90 mg/kg	184.40 ± 16.77^c	39.66 ± 3.66^a	96.94 ± 9.17^a	2.51 ± 0.91^a
270 mg/kg	112.65 ± 6.90^b	35.88 ± 8.60^a	109.31 ± 7.90^ab	2.71 ± 0.78^a
810 mg/kg	83.34 ± 4.81^a	36.09 ± 9.88^a	166.66 ± 10.89^d	2.08 ± 0.66^a
Females
Control	278.25 ± 15.27^c	23.41 ± 3.94^a	80.85 ± 6.17^ab	5.74 ± 1.06^b
30 mg/kg	107.84 ± 6.11^b	24.06 ± 5.23^a	63.94 ± 6.37^a	3.13 ± 0.74^a
90 mg/kg	70.87 ± 6.77^a	27.41 ± 4.92^a	68.89 ± 7.55^a	3.08 ± 0.72^a
270 mg/kg	99.09 ± 13.16^b	26.25 ± 4.35^a	98.59 ± 9.66^b	4.32 ± 1.06^ab
810 mg/kg	66.93 ± 13.02^a	26.91 ± 3.31^a	126.13 ± 16.42^c	3.77 ± 0.85^a

Data are expressed as mean ± SD, n = 4. Values for a given group in a column followed by a different letter as superscript are significantly different according to Waller–Duncan’s multiple comparison test ( < 0.05). ALT: alanine transaminase; AST: aspartate transaminase; ALP: alkaline phosphatase.