Transplacental Transfer of Primaquine and Neurobehavioral Development of Prenatally Exposed Rats

Table 1

Signs of toxicity noted in female rats treated with a single oral or intravenous dose of primaquine (PQ) and observed for 24 h after treatment.

Dose (mg.kg·bw^−1)	Treated rats (N)	Signs of toxicity other than death	Deaths+; N (%)
Oral administration
30	2	No signs of toxicity	0
40	2	Motor hypoactivity, teeth grinding	0
Intravenous administration
5	3	No	0
10	2	Neuromuscular symptoms: hyperactivity followed by coma, tremors, muscle twitches and spasms, and ataxia	1 (50%)
20	1		1 (100%)
30	2		2 (100%)

⁺Toxicity signs and deaths after intravenous administration occurred shortly after treatment, i.e., within 1-2 min at 20 or 30 mg.kg·bw⁻¹ or 5 min following 10 mg.kg·bw⁻¹.