Transplacental Transfer of Primaquine and Neurobehavioral Development of Prenatally Exposed Rats
Table 4
Exploratory behavior (open field test) of the offspring of female rats treated orally with primaquine during pregnancy (GD 0–21) on postnatal day 25.
Maternal treatment during pregnancy
Control (6 ml.kg·bw−1·d−1)
Primaquine (20 mg.kg·bw−1·d−1)
Statistical analysis+
Examined litters (N)
11
11
—
Male offspring
Rearing up (N)
43.8 ± 21.1
27.5 ± 12.5
= 0.03
Locomotor activity (N)
131.8 ± 38.9
108.2 ± 34.8
= 0.15
Time spent within the central circle (s)
8.7 ± 6.9
6.8 ± 4.5
= 0.02
Latency to leave the central circle (s)#
5.9 ± 2.7
7.7 ± 3.0
= 0.16
Grooming episodes (N)
1.6 ± 0.6
2.2 ± 0.7
= 0.07
Fecal boli (N)
4.1 ± 1.7
4.4 ± 1.3
= 0.68
Female offspring
Rearing up (N)
34.6 ± 11.2
24.39 ± 9.6
= 0.03
Locomotor activity (N)
115.6 ± 28.9
97.1 ± 37.4
= 0.09
Time spent within the central circle (s)
9.7 ± 5.3
6.1 ± 6.1
= 0.10
Latency to leave the central circle (s)#
7.9 ± 6.9
7.7 ± 2.8
= 0.93
Grooming episodes (N)
1.6 ± 0.3
2.0 ± 0.7
= 0.09
Fecal boli (N)
4.4 ± 1.8
4.3 ± 2.3
= 0.68
Data are shown as means ± SD. + Student’s t-test. ns: nonsignificant (). The litter was the unit of statistical analysis. #Latency to leave the central circle of OF arena where rats are placed at the beginning of each test session. Time spent in the central circle does not include the initial time (latency) to leave it.
