Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases

Figure 2

The schematic model represents the role of Cd in liver inflammation and the development of NASH, cirrhosis, and HCC. Cd deposition in the liver downregulates glutathione production and increases oxidative stress, mitochondrial dysfunction, and DNA damage. Cd deposition also enhances hepatic steatosis, which leads to an increase in severe liver lesions/damage and HCC progression.