The Developmental Toxicity of Thymus schimperi Essential Oil in Rat Embryos and Fetuses

Table 1

Pregnancy outcome following treatment of pregnant rats with the essential oil of Thymus schimperi: day 12 experiment.

Parameters	Control groups			Treatment groups
	G-I (pair-fed control)	G-II (ad libitum)	G-III (EO 65 mg/kg)	G-IV (EO 130 mg/kg)	G-V (EO 260 mg/kg)
Maternal weight gain per group (g)	3.11 ± 0.20	3.10 ± 0.21	3.31 ± 0.50	3.33 ± 0.07	1.73 ± 0.41^b
Implantation sites per litter	10 ± 0.50	10.1 ± 0.71	9.6 ± 0.03	9.1 ± 0.60	8.2 ± 0.55^b
Resorptions per litter	0.40 ± 0.51	0.35 ± 0.45	0.38 ± 0.50	0.42 ± 0.33	1.01 ± 0.61^b

The data are expressed as mean ± SEM, n = 10 for each group. ^aSignificant difference compared to the pair-fed control group (), ^bsignificant difference compared to the pair-fed control and ad libitum group (), and ^csignificant difference compared to the ad libitum group (). EO: essential oil of Thymus schimperi.