The Developmental Toxicity of Thymus schimperi Essential Oil in Rat Embryos and Fetuses

Table 10

Skeletal malformations of a 20-day-old rat fetuses following treatment with the essential oil of Thymus schimperi.

Group	Percentage of skeletal malformations of limb bones
	Metacarpus^a	Metatarsal^b	Forelimb phalanges^c	Hindlimb phalanges^d
G-I (pair-fed control), n = 50	6	4	10	16
G-II (ad libitum), n = 50	4	4	12	16
G-III (EO 65 mg/kg), n = 50	6	6	12	20
G-IV (EO 130 mg/kg), n = 50	8	6	14	20
G-V (EO 260 mg/kg), n = 50	8	6	14	26

The number of skeletal malformations is expressed as percentage (chi-square). ^a<3 metacarpus; ^b<3 metatarsus; ^cno forelimb proximal phalanges; ^dno hindlimb proximal phalanges.