The Developmental Toxicity of Thymus schimperi Essential Oil in Rat Embryos and Fetuses
Table 2
Embryonic growth following administration of the essential oil of Thymus schimperi leaves.
Parameters
Control groups
Treatment groups
G-I (pair-fed control), n = 120
G-II (ad libitum), n = 116
G-III (EO 65 mg/kg), n = 109
G-IV (EO 130 mg/kg), n = 106
G-V (EO 260 mg/kg), n = 98
Number of somites/litter
29.2 ± 1.1
30.1 ± 0.8
28.7 ± 1.3
28.1 ± 0.8
26.4 ± 0.9 b
CRL of the embryo (mm)
5.0 ± 0.6
5.1 ± 0.4
4.8 ± 0.5
4.6 ± 0.6
4.3 ± 0.7b
Morphological score/litter
46.1 ± 0.2
45.8 ± 0.3
44.7 ± 0.5
44.3 ± 0.4
44.0 ± 0.5b
CRL: crown-rump length; results are expressed as mean ± standard deviation of mean; bmean significantly different from pair-fed and ad libitum control groups; value is <0.05; n: number of embryos; EO: essential oil.
