The Developmental Toxicity of Thymus schimperi Essential Oil in Rat Embryos and Fetuses

Table 8

Visceral malformations of rat fetuses after administration of the essential oil of Thymus schimperi.

Group	Fetus	Observed malformations (%)
	Examined	HC	MO	AO	CP	NSD	REAA	VSD	DH	RA	HU	CT
G-I (pair-fed control)	96	0	0	0	0	0	0	0	0	0	0	0
G-II (ad libitum)	98	0	0	0	0	0	0	0	0	0	0	0
G-III (CT 500 mg/kg)	86	0	0	0	0	0	0	0	0	0	0	0
G-IV (CT 1000 mg/kg)	82	0	0	0	0	0	0	0	0	0	0	0
G-V (CT 2000 mg/kg)	80	0	0	0	0	0	0	0	0	0	0	0

Results are expressed as a percentage of malformations (chi-square). HC: hydrocephalus, MO: microphthalmia, AO: anophthalmia, CP: cleft palate, NSD: nasal septal defect, REAA: retroesophageal aortic arch, VSD: ventricular septal defects, DH: diaphragmatic hernia, RA: renal agenesis, HU: hydroureters, and CT: cryptorchid testes.