Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage

Table 5

Biochemical parameters.

Treatment group	Serum biochemical parameters					P (g/L)	A (g/dL)
	U (mmol/L)	C (μmol/L)	ALP (U/L)	ALT (U/L)	AST (U/L)
Male rats
Control	10.40 ± 0.44^a	61.53 ± 1.62^ab	152.40 ± 12.50^ab	80.20 ± 7.81^a	270.40 ± 15.10^a	72.35 ± 1.34^ab	3.67 ± 0.08^a
40 mg/Kg BW of Y. alpina	10.58 ± 0.84^ab	63.45 ± 1.85^ab	208.20 ± 30.00^ab	64.20 ± 2.58^a	242.00 ± 11.20^a	67.16 ± 1.72^b	3.45 ± 0.21^a
200 mg/Kg BW of Y. alpina	10.51 ± 0.72^ab	58.35 ± 1.02^b	171.00 ± 16.50^ab	63.80 ± 5.28^a	311.00 ± 34.90^a	68.96 ± 1.63^ab	3.47 ± 0.09^a
1000 mg/Kg BW of Y. alpina	12.21 ± 0.49^ab	62.94 ± 1.75^ab	245.60 ± 43.90^a	73.20 ± 13.80^a	288.40 ± 37.90^a	68.63 ± 3.20^ab	3.34 ± 0.15^a
Female rats
Control	7.72 ± 0.60^b	61.53 ± 3.04^ab	81.20 ± 19.10^b	72.80 ± 9.21^a	213.60 ± 9.93^a	76.79 ± 1.71^ab	3.85 ± 0.13^a
40 mg/Kg BW of Y. alpina	8.96 ± 0.56^b	70.52 ± 3.64^a	112.80 ± 43.90^b	55.20 ± 6.50^a	234.60 ± 36.90^a	77.73 ± 4.36^a	3.76 ± 0.18^a
200 mg/Kg BW of Y. alpina	8.35 ± 0.71^b	61.68 ± 1.41^ab	151.80 ± 19.90^ab	63.00 ± 5.30^a	263.40 ± 17.40^a	76.21 ± 0.17^ab	3.64 ± 0.12^a
1000 mg/Kg BW of Y. alpina	8.35 ± 0.71^b	61.68 ± 1.41^ab	151.80 ± 19.90^ab	63.00 ± 5.30^a	263.40 ± 17.40^a	76.21 ± 0.17^ab	3.64 ± 0.12^a

Values are presented as of replicate experiments. Means with similar superscript alphabets within the same column are not significantly different (, One-Way ANOVA with Tukey’s Post hoc); control group rats received 10 ml/Kg BW of distilled water orally. U: urea; C: creatinine; ALP: alkaline phosphate; ALT: alanine aminotransferase; AST: aspartate transaminase; P: total protein; A: albumin.