The Toxic Influence of Excess Free Iron on Red Blood Cells in the Biophysical Experiment: An In Vitro Study

Figure 7

The scheme of the mechanism of the toxic action of excess iron on RBCs, possible distortions in constituent elements of cells, and possible pathophysiological consequences in the clinic. (a) Various factors , which can serve as a source of free iron. (b) Violations in RBCs. 1, 1^/: formation of free iron; 2: fenton reaction. 3, 3^/: ROS formation; 4, 4^/: violations in constituent elements of RBCs; 5, 5^/: pathological processes in RBCs; 6, 6^/: formation of cell-free Hb, free heme. (c) Various clinical consequences . There are indicated positive feedbacks in the process development.