Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats

Table 10

Effect of GutGard on relative organ weights (%) of male rats during 90 D oral toxicity study.

Parameter	Dose (mg/kg)
	0	0 (Rev)^$	250	500	1000	1000 (Rev)^$
Brain	0.525 ± 0.052	0.490 ± 0.054	0.544 ± 0.056	0.545 ± 0.033	0.562 ± 0.067	0.531 ± 0.041
Liver	3.026 ± 0.639	3.083 ± 0.387	3.059 ± 0.415	3.497 ± 0.409	3.762 ± 0.361	3.013 ± 0.155
Kidneys	0.705 ± 0.082	0.734 ± 0.046	0.726 ± 0.069	0.749 ± 0.054	0.827 ± 0.051	0.697 ± 0.045
Adrenals	0.0131 ± 0.0018	0.0115 ± 0.0014	0.0159 ± 0.0040	0.0148 ± 0.0014	0.0153 ± 0.0022	0.0114 ± 0.0020
Testes	0.766 ± 0.095	0.743 ± 0.065	0.823 ± 0.087	0.818 ± 0.079	0.825 ± 0.106	0.755 ± 0.059
Heart	0.322 ± 0.038	0.339 ± 0.046	0.330 ± 0.045	0.344 ± 0.061	0.333 ± 0.024	0.353 ± 0.033
Spleen	0.371 ± 0.133	0.281 ± 0.058	0.297 ± 0.095	0.364 ± 0.074	0.399 ± 0.073	0.253 ± 0.036
Thymus	0.056 ± 0.018	0.043 ± 0.015	0.044 ± 0.017	0.056 ± 0.016	0.042 ± 0.010	0.039 ± 0.007
Epididymis	0.320 ± 0.037	0.294 ± 0.040	0.300 ± 0.041	0.305 ± 0.023	0.326 ± 0.039	0.284 ± 0.019

Mean ± SD (n = 10); ^$n = 5; Rev.: reversal.  = significant at 95% level of confidence (p ≤ 0.05);  = significant at 99% level of confidence .