Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats

Table 11

Effect of GutGard on absolute organ weights (g) of female rats during 90 D oral toxicity study.

Parameter	Dose (mg/kg)
	0	0 (Rev)^$	250	500	1000	1000 (Rev)^$
TBD (g)	246.48 ± 19.99	260.50 ± 8.18	239.39 ± 18.31	230.75 ± 14.55	239.63 ± 18.72	249.70 ± 27.05
Brain	1.776 ± 0.160	1.851 ± 0.161	1.846 ± 0.107	1.845 ± 0.067	1.858 ± 0.061	1.804 ± 0.104
Liver	6.904 ± 0.738	7.848 ± 0.708	6.926 ± 0.492	7.532 ± 1.042	8.896 ± 1.333	7.137 ± 0.491
Kidneys	1.645 ± 0.133	1.692 ± 0.164	1.599 ± 0.122	1.729 ± 0.127	1.685 ± 0.081	1.542 ± 0.100
Adrenals	0.0641 ± 0.0151	0.0605 ± 0.0193	0.0568 ± 0.0067	0.0665 ± 0.0100	0.0642 ± 0.0156	0.0582 ± 0.0055
Ovaries	0.0838 ± 0.0233	0.1216 ± 0.0212	0.0787 ± 0.0150	0.0982 ± 0.0161	0.0920 ± 0.0221	0.0977 ± 0.0166
Heart	0.794 ± 0.081	1.002 ± 0.063	0.858 ± 0.061	0.842 ± 0.115	0.863 ± 0.074	0.809 ± 0.128
Spleen	0.870 ± 0.169	0.966 ± 0.157	0.772 ± 0.150	0.891 ± 0.199	0.922 ± 0.173	0.741 ± 0.039
Thymus	0.150 ± 0.051	0.188 ± 0.050	0.170 ± 0.040	0.187 ± 0.052	0.145 ± 0.062	0.146 ± 0.061
Uterus	0.358 ± 0.138	0.483 ± 0.091	0.377 ± 0.086	0.374 ± 0.114	0.336 ± 0.049	0.450 ± 0.100

Mean ± SD (n = 10); ^$n = 5; Rev.: reversal; TBD: total body weight.